The seizure threshold following short wavetrains of high-frequency electrical stimuli (0.5ms pulses at 200Hz for 300ms) is increased in mutant flies (52.9 +/- 7.4 V) compared to controls.
The threshold for activation of the giant fiber in mutant animals following single stimulus pulses (0.2ms duration, 0.5Hz) is not significantly different from that of wild type.
slounspecified "giant" neurons derived from embryonic neuroblasts cultured in the presence of cytochalasin B exhibit prolonged action potentials. This phenotype appears to be more pronounced in the neurites than in the soma.
A single-channel Ca2+-activated K+ channel that can be readily distinguished in wild-type larval muscle membrane preparations is not observed in slounspecified muscle membrane preparations.
Ca2+-activated K+ current (ICF) does not show a gene dosage effect in heterozygous muscles.