FB2024_03 , released June 25, 2024
Allele: Hsap\ELK1DN.UAS.cGa
Open Close
General Information
Symbol
Hsap\ELK1DN.UAS.cGa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Guillemin
FlyBase ID
FBal0052311
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of a dominant-negative form of Hsap\ELK1 (encodes a protein that is truncated after amino acid residue 307, and is thus missing the transcriptional activation domain).

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

When expressed under the influence of Scer\GAL4tracheal, phenotype is very similar to that of bs03267. Terminal tracheal branches were truncated or absent. In larvae, the parental branches end abruptly without ramification. The terminal cells of mutant embryos do not have long projections extending to their targets. No muscle defects can be detected in mutant embryos.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Hsap\ELK1DN.Scer\UAS.cGa
Hsap\ELK1DN.UAS.cGa
Hsap\ELK1Scer\UAS.cGa
Hsap\ELK1UAS.cGa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Guillemin
Secondary FlyBase IDs
    References (1)