FB2024_03 , released June 25, 2024
Allele: Dmel\sns23
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General Information
Symbol
Dmel\sns23
Species
D. melanogaster
Name
FlyBase ID
FBal0046379
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
rost23
Key Links
Nature of the Allele
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In mutant embryos, the muscle founder cells are restricted to the ventral part of the visceral band and become less elongated. Within these cells some nuclei move into a more dorsal position, but no signs of myoblast fusion are visible. At the dorsal side, there are many unfused globular cells, which in wild-type embryos have already fused with the ventral myoblasts at that stage of development. All fusion competent myoblasts retain their globular shape. During further differentiation the spindle-like founder cells stretch out ventrally and dorsally. Although no fusion processes are seen, these cells can differentiate to a certain degree. At stage 16, besides the absence of the first midgut constriction severe aberrations are seen in the visceral musculature of the anterior part of them midgut. In comparison to wild-type the longitudinal muscles are almost absent and circular muscles are completely disorganised.

Homozygous stage 14 embryos contain a high number of unfused myoblasts.

Dorsal vessel and visceral mesoderm is unaffected but major distortions occur in somatic mesoderm. Strong allele: Late stages of embryonic development show mostly unfused myoblasts. First distortions are visible during germ-band retraction. Unfused myoblasts are often arranged in specific locations where in the wild type ventral, pleural and longitudinal muscles form.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a mutation that shows lethality over the "rost30A" chromosome. The "rost30A" chromosome contains mutations in two genes: rost30A and sns43-49. sns23 has been shown to be allelic to sns43-49 rather than to rost30A.

Comments
Comments

Not rescued by: rosttPa.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)