FB2024_03 , released June 25, 2024
Allele: Dmel\perLR
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General Information
Symbol
Dmel\perLR
Species
D. melanogaster
Name
FlyBase ID
FBal0046271
Feature type
allele
Associated gene
Dmel\per
Associated Insertion(s)
Carried in Construct
P{perLR}
Also Known As
perLR
Key Links
Transgenic product class
missense_variant
(Curtin et al., 1995)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Curtin et al., 1995)
Mutagen
in vitro construct
(Curtin et al., 1995, Huang et al., 1995)
Progenitor genotype
per+t13.2
(Curtin et al., 1995)
Carried in construct
P{perLR}
Cytology
Description

Amino acid replacement: V243R.

(Curtin et al., 1995)

Genomic fragment that includes the complete per gene. A V243R amino acid replacement has been introduced into the coding sequence. This mutation is the same lesion as found in perL1.

(Huang et al., 1995)
Allele components
Component
Use(s)
Regulatory region(s)
per
Encoded product / tool
per
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Circadian period is 28 hours, timSL can shorten the rhythm to 25 hours.

      (Rutila et al., 1996)

      Free running period of 28.5 hours.

      (Curtin et al., 1995)

      Phenotype is as for perL1 : lengthened and temperature-sensitive circadian period.

      (Huang et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      per nuclear translocation in pacemaker neurons is delayed compared to wild type, this delay is temperature sensitive.

      (Curtin et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      perLR
      (Rutila et al., 1996, Curtin et al., 1995)
      perLR
      Name Synonyms
      Secondary FlyBase IDs
        References (3)