FB2024_03 , released June 25, 2024
Allele: Dmel\pdm2E46
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General Information
Symbol
Dmel\pdm2E46
Species
D. melanogaster
Name
FlyBase ID
FBal0046250
Feature type
allele
Associated gene
Dmel\pdm2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Yeo et al., 1995)
Mutagen
ethyl methanesulfonate
(Yeo et al., 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q185term.

(Yeo et al., 1995)

The mutation is predicted to produce a truncated protein that lacks the POU (DNA binding) domain.

(Yeo et al., 1995)

Nucleotide substitution: C?T.

(Yeo et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:12,684,881..12,684,881 [+]
Nucleotide change:

C12684881T

Reported nucleotide change:

C?T

Amino acid change:

Q185term | pdm2-PA; Q580term | pdm2-PB; Q580term | pdm2-PC; Q580term | pdm2-PD

Reported amino acid change:

Q185term

(Yeo et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lethal when heterozygous with Df(2L)prd1.7 and viable when heterozygous with Df(2L)Prl. Homozygotes exhibit defects in the formation of the RP2 motoneuron. Number of hemisegments with a mature RP2 neuron in homozygous embryos is reduced to 76%, loss of RP2 phenotype. The failure to produce mature RP2 neurons is attributable, at least in part, to GMC4-2a adopting an aberrant cell identity. Heterozygotes with Df(2L)pdm-2PR6 have only 80% of hemisegments with a mature RP2 neuron. P{HSpdm-1} can restore at least some of the mature RP2 motoneurons in pdm2E46/Df(2L)prd1.7 embryos, in which mature motoneurons are not made.

      (Yeo et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pdm-2E46
      (Yeo et al., 1995)
      pdm2E46
      (Loker and Mann, 2022, Kao et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)