FB2024_03 , released June 25, 2024
Allele: Dmel\insc8
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General Information
Symbol
Dmel\insc8
Species
D. melanogaster
Name
FlyBase ID
FBal0046161
Feature type
allele
Associated gene
Dmel\insc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Knirr, 1996.4.30, Burchard et al., 1995)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      abdominal 1 lateral adult muscle precursor cell

      (Ruiz Gomez and Bate, 1997)

      abdominal 1 ventral oblique muscle cell

      (Knirr et al., 1997)

      abdominal 2 lateral adult muscle precursor cell

      (Ruiz Gomez and Bate, 1997)

      abdominal 2 ventral oblique muscle cell

      (Knirr et al., 1997)

      abdominal 3 lateral adult muscle precursor cell

      (Ruiz Gomez and Bate, 1997)

      abdominal 3 ventral oblique muscle cell

      (Knirr et al., 1997)

      abdominal 4 lateral adult muscle precursor cell

      (Ruiz Gomez and Bate, 1997)

      abdominal 4 ventral oblique muscle cell

      (Knirr et al., 1997)

      abdominal 5 lateral adult muscle precursor cell

      (Ruiz Gomez and Bate, 1997)

      abdominal 5 ventral oblique muscle cell

      (Knirr et al., 1997)

      abdominal 6 lateral adult muscle precursor cell

      (Ruiz Gomez and Bate, 1997)

      abdominal 6 ventral oblique muscle cell

      (Knirr et al., 1997)

      abdominal 7 lateral adult muscle precursor cell

      (Ruiz Gomez and Bate, 1997)

      abdominal 7 ventral oblique muscle cell

      (Knirr et al., 1997)

      abdominal 8 ventral oblique muscle cell

      (Knirr et al., 1997)

      abdominal adult muscle precursor cell

      (Ruiz Gomez and Bate, 1997)

      hypodermal muscle cell of larval abdominal 9

      (Knirr et al., 1997)

      mesothoracic ventral oblique muscle cell

      (Knirr et al., 1997)

      metathoracic ventral oblique muscle cell

      (Knirr et al., 1997)

      muscle cell of abdominal 1 lateral transverse muscle 3

      (Ruiz Gomez and Bate, 1997)

      muscle cell of abdominal 2 lateral transverse muscle 3

      (Ruiz Gomez and Bate, 1997)

      muscle cell of abdominal 3 lateral transverse muscle 3

      (Ruiz Gomez and Bate, 1997)

      muscle cell of abdominal 4 lateral transverse muscle 3

      (Ruiz Gomez and Bate, 1997)

      muscle cell of abdominal 5 lateral transverse muscle 3

      (Ruiz Gomez and Bate, 1997)

      muscle cell of abdominal 6 lateral transverse muscle 3

      (Ruiz Gomez and Bate, 1997)

      muscle cell of abdominal 7 lateral transverse muscle 3

      (Ruiz Gomez and Bate, 1997)

      somatic muscle cell | dorsal

      (Burchard et al., 1995)

      somatic muscle cell | lateral

      (Burchard et al., 1995)

      somatic muscle cell | ventral

      (Burchard et al., 1995)
      Detailed Description
      Statement
      Reference

      Homozygous embryos exhibit five ventral oblique muscles instead of three (as in wild type embryos). Embryonic muscle loss is due to defects in early somatic differentiation. Severe abnormalities are observed in a subset of pericardial cells.

      (Knirr et al., 1997)

      Supernumerary muscles develop at the expense of the adult muscle precursors in homozygous embryos. The segment border muscle is duplicated at the expense of the lateral adult muscle precursors. Muscle LT3 is transformed to LT4.

      (Ruiz Gomez and Bate, 1997)

      Fusion defects of myoblasts.

      (Knirr et al., 1996)

      Muscle pattern is reduced (ventral and pleural muscles) and disorganised (ventral lateral and dorsal muscles). The dorsal vessel is fairly normal. Most dorsal muscles are formed and inserted appropriately in the apodemes. Pattern formation of the cuticle is normal suggesting the observed muscle phenotype is not a consequence of epidermis defects.

      (Burchard et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      insc8
      nem8
      (Ruiz Gomez and Bate, 1997)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)