FB2024_03 , released June 25, 2024
Allele: Dmel\insc3
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General Information
Symbol
Dmel\insc3
Species
D. melanogaster
Name
FlyBase ID
FBal0046160
Feature type
allele
Associated gene
Dmel\insc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Knirr, 1996.4.30, Burchard et al., 1995)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      abdominal 1 lateral pentascolopidial chordotonal organ lch5

      (Burchard et al., 1995)

      abdominal 1 segment border muscle cell

      (Knirr et al., 1997)

      abdominal 1 ventral longitudinal muscle cell

      (Knirr et al., 1997)

      abdominal 2 lateral pentascolopidial chordotonal organ lch5

      (Burchard et al., 1995)

      abdominal 2 segment border muscle cell

      (Knirr et al., 1997)

      abdominal 2 ventral longitudinal muscle cell

      (Knirr et al., 1997)

      abdominal 3 lateral pentascolopidial chordotonal organ lch5

      (Burchard et al., 1995)

      abdominal 3 segment border muscle cell

      (Knirr et al., 1997)

      abdominal 3 ventral longitudinal muscle cell

      (Knirr et al., 1997)

      abdominal 4 lateral pentascolopidial chordotonal organ lch5

      (Burchard et al., 1995)

      abdominal 4 segment border muscle cell

      (Knirr et al., 1997)

      abdominal 4 ventral longitudinal muscle cell

      (Knirr et al., 1997)

      abdominal 5 lateral pentascolopidial chordotonal organ lch5

      (Burchard et al., 1995)

      abdominal 5 segment border muscle cell

      (Knirr et al., 1997)

      abdominal 5 ventral longitudinal muscle cell

      (Knirr et al., 1997)

      abdominal 6 lateral pentascolopidial chordotonal organ lch5

      (Burchard et al., 1995)

      abdominal 6 segment border muscle cell

      (Knirr et al., 1997)

      abdominal 6 ventral longitudinal muscle cell

      (Knirr et al., 1997)

      abdominal 7 lateral pentascolopidial chordotonal organ lch5

      (Burchard et al., 1995)

      abdominal 7 segment border muscle cell

      (Knirr et al., 1997)

      abdominal 7 ventral longitudinal muscle cell

      (Knirr et al., 1997)

      abdominal 8 ventral longitudinal muscle cell

      (Knirr et al., 1997)

      hypodermal muscle cell of larval abdominal 9

      (Knirr et al., 1997)

      mesothoracic lateral transverse muscle cell

      (Knirr et al., 1997)

      mesothoracic segment border muscle cell

      (Knirr et al., 1997)

      mesothoracic ventral longitudinal muscle cell

      (Knirr et al., 1997)

      metathoracic lateral transverse muscle cell

      (Knirr et al., 1997)

      metathoracic segment border muscle cell

      (Knirr et al., 1997)

      metathoracic ventral longitudinal muscle cell

      (Knirr et al., 1997)

      muscle cell of abdominal 1 lateral longitudinal muscle 1

      (Knirr et al., 1997)

      muscle cell of abdominal 1 ventral oblique muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 1 ventral oblique muscle 2

      (Burchard et al., 1995)

      muscle cell of abdominal 1 ventral oblique muscle 3

      (Burchard et al., 1995)

      muscle cell of abdominal 2 lateral longitudinal muscle 1

      (Knirr et al., 1997)

      muscle cell of abdominal 2 ventral oblique muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 2 ventral oblique muscle 2

      (Burchard et al., 1995)

      muscle cell of abdominal 2 ventral oblique muscle 3

      (Burchard et al., 1995)

      muscle cell of abdominal 3 lateral longitudinal muscle 1

      (Knirr et al., 1997)

      muscle cell of abdominal 3 ventral oblique muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 3 ventral oblique muscle 2

      (Burchard et al., 1995)

      muscle cell of abdominal 3 ventral oblique muscle 3

      (Burchard et al., 1995)

      muscle cell of abdominal 4 lateral longitudinal muscle 1

      (Knirr et al., 1997)

      muscle cell of abdominal 4 ventral oblique muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 4 ventral oblique muscle 2

      (Burchard et al., 1995)

      muscle cell of abdominal 4 ventral oblique muscle 3

      (Burchard et al., 1995)

      muscle cell of abdominal 5 lateral longitudinal muscle 1

      (Knirr et al., 1997)

      muscle cell of abdominal 5 ventral oblique muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 5 ventral oblique muscle 2

      (Burchard et al., 1995)

      muscle cell of abdominal 5 ventral oblique muscle 3

      (Burchard et al., 1995)

      muscle cell of abdominal 6 lateral longitudinal muscle 1

      (Knirr et al., 1997)

      muscle cell of abdominal 6 ventral oblique muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 6 ventral oblique muscle 2

      (Burchard et al., 1995)

      muscle cell of abdominal 6 ventral oblique muscle 3

      (Burchard et al., 1995)

      muscle cell of abdominal 7 lateral longitudinal muscle 1

      (Knirr et al., 1997)

      muscle cell of abdominal 7 ventral oblique muscle 1

      (Burchard et al., 1995)

      muscle cell of abdominal 7 ventral oblique muscle 2

      (Burchard et al., 1995)

      muscle cell of abdominal 7 ventral oblique muscle 3

      (Burchard et al., 1995)

      muscle cell of mesothoracic lateral longitudinal muscle 1

      (Burchard et al., 1995)

      muscle cell of metathoracic ventral oblique muscle 1

      (Burchard et al., 1995)

      muscle cell of metathoracic ventral oblique muscle 2

      (Burchard et al., 1995)

      muscle cell of metathoracic ventral oblique muscle 3

      (Burchard et al., 1995)

      pericardial cell | embryonic stage

      (Knirr et al., 1997)
      Detailed Description
      Statement
      Reference

      Homozygous embryos exhibit loss of some VL and LT muscles as well as a duplication of SBM muscle. Embryonic muscle loss is due to defects in early somatic differentiation. Severe abnormalities are observed in a subset of pericardial cells.

      (Knirr et al., 1997)

      Fusion defects of myoblasts.

      (Knirr et al., 1996)

      Dorsal vessel develops properly. Embryos exhibit muscle reduction in only one or two abdominal segments. Pleural and ventrolateral muscles shows distortions. Pattern formation of the cuticle is normal suggesting the observed muscle phenotype is not a consequence of epidermis defects. Peripheral nervous system is reduced, chordotonal organs are affected while the dorsal hair sensilla are unchanged. Ventral cord exhibits no gross defects.

      (Burchard et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Weak allele.

      (Burchard et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      insc3
      nem3
      Name Synonyms
      Secondary FlyBase IDs
        References (4)