FB2024_03 , released June 25, 2024
Allele: Dmel\l(1)scUAS.cCa
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General Information
Symbol
Dmel\l(1)scUAS.cCa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Carmena
FlyBase ID
FBal0045935
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-l'sc
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

Expression of l(1)sc coding region is governed by UASt regulatory sequences.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

When expression of l(1)scScer\UAS.cCa is driven by Scer\GAL4W381 the mutant muscle 25 phenotype of Df(1)sc19 is substantially rescued. The CNS defect of Df(1)sc19 is not rescued. In an otherwise wild type background there is a variable phenotype in which muscles are duplicated. The expressivity of this muscle duplication is increased by driving expression of l(1)scScer\UAS.cCa by Scer\GAL4how-24B Scer\GAL4twi.PG.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

When E(spl)Scer\UAS.cNa and l(1)scScer\UAS.cCa are simultaneously driven by Scer\GAL4da.G32, neural hypoplasia effects are much weaker than those caused by E(spl)Scer\UAS.cNa alone, especially in the PNS. When E(spl)Scer\UAS.cNa and l(1)scScer\UAS.cCa are simultaneously driven by Scer\GAL4sca-537.4, ectopic sense organs caused by l(1)scScer\UAS.cCa are much reduced.

Scer\GAL4sca-4512-mediated expression fails to rescue the MP2 phenotype of homozygous In(1)y3PLsc8R embryos.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
l(1)scScer\UAS.cCa
l(1)scUAS.cCa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Carmena
Secondary FlyBase IDs
    References (6)