FB2024_03 , released June 25, 2024
Allele: Dmel\cncC7
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General Information
Symbol
Dmel\cncC7
Species
D. melanogaster
Name
FlyBase ID
FBal0045475
Feature type
allele
Associated gene
Dmel\cnc
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(McGinnis et al., 1998)
Progenitor genotype
Cytology
Description

No nucleotide substitutions are detected in any of the cnc open reading frames or splice junctions.

(McGinnis et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes or transheterozygotes with cnc2E16 display ectopic mouth hooks and cirri in the mandibular region, indicating a mandibular to maxillary transformation. The median tooth, dorsal bridge and other more anteriorly derived structures appear to be unaffected. Transheterozygotes with cncVL110 have the mandibular to maxillary transformation and nearly normal median tooth and dorsal bridge.

      (Harding et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Loss of function phenotype differs from that expected of cnc loss of function mutations but the allele has been provisionally classified as cnc based on meiotic map position and failure to complement cncVL110.

      (Harding et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      cncC7
      Name Synonyms
      Secondary FlyBase IDs
        References (2)