FB2024_03 , released June 25, 2024
Allele: Dmel\UbxmABP
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General Information
Symbol
Dmel\UbxmABP
Species
D. melanogaster
Name
FlyBase ID
FBal0045267
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Carried in construct
Cytology
Description

Ubx expression is governed by the Ubx proximal promoter (-3.1kb to +1kb) together with the ABX, BXD and PBX regulatory fragments, the ABX being closest to the promoter.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies carrying UbxmABP have a strong UbxCbx-1-like phenotype. Can almost completely rescue homeotic transformations of the haltere disc derivatives (dorsal T3a or T3p) caused by various Ubx mutations. Can also partially rescue the A1a to T3a transformation seen in Ubx1/Ubxbxd-1 flies. Can rescue Ubx1 homozygotes from larval lethality to pupal stages. A small fraction of these animals survive to the end of pupation and secrete adult epidermis which is fully differentiated. Can completely rescue the "ppx" phenotype (T2p to T1p) of Ubx1 homozygotes and Ubx1/Ubx195 transheterozygotes.

The minigene provides Ubx function in ps5 and ps6 of the embryonic epidermis, rescuing some of the most conspicuous aspects of the larval Ubx- phenotype. Can rescue Ubx1 homozygotes from larval lethality to late pupal stages.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
UbxmABP
Name Synonyms
Secondary FlyBase IDs
    References (2)