FB2024_03 , released June 25, 2024
Allele: Dmel\PTKP1
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General Information
Symbol
Dmel\P\TKP1
Species
D. melanogaster
Name
FlyBase ID
FBal0033946
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

1.1kb internally deleted P element. Deleted for bp 809 to bp 2563, with a 2bp ambiguity due to duplicate sequences at the deletion breakpoints.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

P{KP}2F represses the P\TCP.hs transposase activity encoded by H{hsp/CP}2; the rate of snw mutation (in the absence of heat shock) in the male germline caused by H{hsp/CP}2 is reduced if P{KP}2F is present. P{KP}2F represses the transposase activity of P{Δ2-3}99B in the germline; the rate of snw mutation in the male germline caused by P{Δ2-3}99B is reduced if P{KP}2F is present.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Does not significantly suppress the vg21-3 mutant phenotype. Represses gonadal dysgenesis and snw mutability, suppressing snw mutability more strongly than P\TKP6.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Three independent insertions of this element behaved differently in snw mutability and gonadal dysgenesis tests, indicating that site of insertion into the genome may play a role in defining these different activities.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)