FB2024_03 , released June 25, 2024
Allele: Dmel\ninaCΔ174
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General Information
Symbol
Dmel\ninaCΔ174
Species
D. melanogaster
Name
FlyBase ID
FBal0032277
Feature type
allele
Associated gene
Dmel\ninaC
Associated Insertion(s)
Carried in Construct
P{ninaCΔ174}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Porter et al., 1992)
Progenitor genotype
Carried in construct
P{ninaCΔ174}
Cytology
Description

Construct: The second base of the tenth intron of the 4.8kb ninaC mRNA is changed from a T to a G. This specifically eliminates expression of the p174 ninaC protein.

(Porter et al., 1992)
Allele components
Component
Use(s)
Encoded product / tool
ninaC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing ninaCΔ174 in a ninaC5 background show similar rates of termination of the photoresponse (measured using an electroretinogram recording) as wild-type flies after pre-exposure to light.

      (Lee and Montell, 2004)

      Like ninaC5, but unlike ninaCΔ132, photoreceptors treated with 8-Br-cAMP or IBMX show no alteration in the kinetics of the macroscopic light response.

      (Chyb et al., 1999)

      Voltage clamped flash response shows delayed response termination. Plateau responses are also large in response to steady light. Also exhibits quantam bump-like activity in the dark and larger and longer bumps in the light. Turn-off to the pupil mechanisms is defective and the pupillary pigment migration is smaller than that in wild type.

      (Hofstee et al., 1996)

      The electroretinogram of young ninaC5 flies carrying ninaCΔ174 reared in the dark is similar to that of ninaC5 mutant flies. ninaC5 flies carrying ninaCΔ174 show the same time course of retinal degeneration as ninaC5 flies.

      (Porter et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ninaCΔ174
      (Mecklenburg et al., 2010, Venkatachalam et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)