FB2024_03 , released June 25, 2024
Allele: Dmel\esgGW2
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General Information
Symbol
Dmel\esgGW2
Species
D. melanogaster
Name
FlyBase ID
FBal0031211
Feature type
allele
Associated gene
Dmel\esg
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Hayashi et al., 1993)
    Mutagen
    Progenitor genotype
    Caused by aberration
    Df(2L)TE35D-2
    Cytology
    Description

    Proximal breakpoint hits esg.

    (Roote, 1996.8)

    Deficiency removing a small part of the upstream region.

    (Fuse et al., 1994)

    Breakpoint of Df(2L)TE35D-2 near esg locus.

    (Hayashi et al., 1993)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Heterozygotes with esgL2 are viable with reduced abdominal cuticle and bristles. Introduction of P{HS-esg.F} and multiple heat shocks increases the number of bristles.

        (Fuse et al., 1994)

        Viable or semi-viable in combination with esg point mutants. Flies have held-out wings and deleted sternites/tergites and/or twisted legs. Exception is with esgL7, where flies phenotypically wild type. Abdominal histoblasts examined in heteroallelic combinations and found to have nuclei 3.4 fold times larger (revealed by Ecol\lacZ expression from esg05729 allele) and with 7-16 times as much DNA (DAPI fluorescence) as wild type histoblast nuclei.

        (Hayashi et al., 1993)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        esgGW2
        Name Synonyms
        Secondary FlyBase IDs
          References (4)