FB2024_03 , released June 25, 2024
Allele: Dmel\awdKRN3
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General Information
Symbol
Dmel\awdKRN3
Species
D. melanogaster
Name
FlyBase ID
FBal0030536
Feature type
allele
Associated gene
Dmel\awd
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Timmons et al., 1993)
Mutagen
ethyl methanesulfonate
(Timmons et al., 1993)
Progenitor genotype
awdK
(Timmons et al., 1993)
Cytology
Description

Molecular modification is relative to the progenitor, awdK.

(Timmons et al., 1993)

Amino acid replacement: R89C.

(Timmons et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:31,745,455..31,745,455 [-]
Nucleotide change:

C31745455T

Amino acid change:

R104C | awd-PC; R104C | awd-PD; R89C | awd-PE

Reported amino acid change:

R89C

Comment:

induced on awdK chromosome

(Timmons et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      awdKRN3 homozygous embryos exhibit major disruption of the tracheal network accompanied by ectopic branching and looping, appearance of a few extra branches or "knobs", and migration abnormalities.

      (Dammai et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      awdKRN3
      Name Synonyms
      Secondary FlyBase IDs
        References (2)