FB2024_03 , released June 25, 2024
Allele: Dmel\aphs.PB
Open Close
General Information
Symbol
Dmel\aphs.PB
Species
D. melanogaster
Name
heat shock construct of Bourgouin
FlyBase ID
FBal0030503
Feature type
allele
Associated gene
Dmel\ap
Associated Insertion(s)
Carried in Construct
P{hs-ap}
Key Links
Transgenic product class
cDNA
(Bourgouin et al., 1992)
wild_type
(Bourgouin et al., 1992)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Bourgouin et al., 1992)
wild_type
(Bourgouin et al., 1992)
Mutagen
in vitro construct
(Benveniste et al., 1998, Becker et al., 1997, Bourgouin et al., 1992)
Progenitor genotype
Carried in construct
P{hs-ap}
Cytology
Description

ap cDNA expression is driven by an Hsp70 promoter.

(Bourgouin et al., 1992)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
ap
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      dorsal longitudinal indirect flight muscle cell

      (Bernard et al., 2003)

      muscle cell of abdominal 2 lateral transverse muscle 1

      (Bourgouin et al., 1992)

      muscle cell of abdominal 2 lateral transverse muscle 2

      (Bourgouin et al., 1992)

      muscle cell of abdominal 2 lateral transverse muscle 3

      (Bourgouin et al., 1992)

      muscle cell of abdominal 3 lateral transverse muscle 1

      (Bourgouin et al., 1992)

      muscle cell of abdominal 3 lateral transverse muscle 2

      (Bourgouin et al., 1992)

      muscle cell of abdominal 3 lateral transverse muscle 3

      (Bourgouin et al., 1992)

      muscle cell of abdominal 4 lateral transverse muscle 1

      (Bourgouin et al., 1992)

      muscle cell of abdominal 4 lateral transverse muscle 2

      (Bourgouin et al., 1992)

      muscle cell of abdominal 4 lateral transverse muscle 3

      (Bourgouin et al., 1992)

      muscle cell of abdominal 5 lateral transverse muscle 1

      (Bourgouin et al., 1992)

      muscle cell of abdominal 5 lateral transverse muscle 2

      (Bourgouin et al., 1992)

      muscle cell of abdominal 5 lateral transverse muscle 3

      (Bourgouin et al., 1992)

      muscle cell of abdominal 6 lateral transverse muscle 1

      (Bourgouin et al., 1992)

      muscle cell of abdominal 6 lateral transverse muscle 2

      (Bourgouin et al., 1992)

      muscle cell of abdominal 6 lateral transverse muscle 3

      (Bourgouin et al., 1992)

      muscle cell of abdominal 7 lateral transverse muscle 1

      (Bourgouin et al., 1992)

      muscle cell of abdominal 7 lateral transverse muscle 2

      (Bourgouin et al., 1992)

      muscle cell of abdominal 7 lateral transverse muscle 3

      (Bourgouin et al., 1992)

      wing

      (Blair et al., 1994)
      Detailed Description
      Statement
      Reference

      Degeneration of dorsal medial muscles occurs in aphs.PB flies under various heat shock regimes with the most deleterious effect of these muscles occurring when heat shocks are performed between ...

      (Bernard et al., 2003)

      Larvae which have been treated overnight with heat shocks produce adults with a variety of wing defects, ranging from nicks to wing reductions.

      (Blair et al., 1994)

      When 6-7 hour old embryos homozygous for aphs.PB were heat shocked for 45 minutes at 37oC, two or three extra muscles appear in the position of muscles 21, 22 and 23 (which normally express ap) in segments A1 to A7. No other muscles are affected, either by being duplicated or deleted.

      (Bourgouin et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      This phenotype resembles that of the dominant apXa allele.

      (Blair et al., 1994)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      aphs.PB
      Name Synonyms
      heat shock construct of Bourgouin
      Secondary FlyBase IDs
        References (5)