FB2024_03 , released June 25, 2024
Allele: Dmel\Sbsbd-VX1
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General Information
Symbol
Dmel\Sbsbd-VX1
Species
D. melanogaster
Name
FlyBase ID
FBal0028540
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutagen
Progenitor genotype
Caused by aberration
Cytology
Description

In(3R)sbdVX1 breaks between the first and second exon of the Sb transcript, between -65 and -70kb.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

microchaeta & actin filament

microchaeta & actin filament (with Df(3R)sbd45)

Detailed Description
Statement
Reference

The microchaetae of Sbsbd-VX1 mutants are shorter, fatter and straighter than in wild type. Further, Sbsbd-VX1 microchaetae contain twice the number of actin bundles compared to wild type and these bundles are linked by more cross-bridges than in wild type. During development, these bristles grow more slowly than in wild type; the bristles therefore experience less constraint from the inner pupal case than wild-type bristles, which could account for the lack of curvature seen in the mutant bristles.

Longitudinal actin bundles in the bristle cells of Sbsbd-VX1/Df(3R)sbd45 mutants exhibit a triangular cross-sectional profile that is larger than wild type. The filaments are packed hexagonally, like in wild type.

First difference from wild type evident at around 40 hours of pupal development, when the number of actin filament bundles becomes abruptly reduced, then disorganised at the tip accounting for the resulting frayed bristle ends.

phenotype more extreme when homozygous than when hemizygous; may not be null.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

More severe phenotype as a homozygote than over a deficiency, suggesting that it is not a true null.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Sbsbd-VX1
Name Synonyms
Secondary FlyBase IDs
    References (6)