FB2024_03 , released June 25, 2024
Allele: Dmel\tra21
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General Information
Symbol
Dmel\tra21
Species
D. melanogaster
Name
FlyBase ID
FBal0017020
Feature type
allele
Associated gene
Dmel\tra2
Associated Insertion(s)
Carried in Construct
Also Known As
tra-2, tra-21
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

Mutagen
spontaneous
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Females exhibit segment spanning muscles in the fifth abdominal segment indicative of a transformation to the male specific phenotype. Somatic development of males is unaffected.

      (Taylor, 1992)

      virts/virts tra21/+ XX flies are pseudomales at 29oC, indicating that tra2 is epistatic to vir.

      (Hilfiker and Nothiger, 1991)

      Homozygous XX flies are transformed into male-like animals.

      (Schupbach, 1982)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      XX tra21/tra2B ; bonS043420/bonS043420 animals, that are genetically female (XX) but phenotypically male are viable.

      (Beckstead et al., 2005)

      traF.Hsp83 is unable to feminise the soma of XY or XX tra21/Df(2R)trix animals. In both cases, the external morphology of the flies is male-like. In the XY flies, the overall morphology of the gonad is male-like, but they are sterile.

      (Waterbury et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Homozygous XX flies have no Yp1, Yp2 or Yp3 proteins in the haemolymph.

      (Ota et al., 1981)

      Germ line clonal analysis and pole cell transplantation experiments show that tra2 function is not required in the germ line for the normal development of germ cells according to their chromosomal sex.

      (Schupbach, 1982)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      tra-2
      (Waterbury et al., 2000, Schupbach, 1982, Ota et al., 1981)
      tra-21
      (Beckstead et al., 2005, Oliver et al., 1993)
      tra2
      (Hilfiker and Nothiger, 1991)
      tra21
      (Hudry et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (17)