FB2024_03 , released June 25, 2024
Allele: Dmel\shi21
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General Information
Symbol
Dmel\shi21
Species
D. melanogaster
Name
FlyBase ID
FBal0015630
Feature type
allele
Associated gene
Dmel\shi
Associated Insertion(s)
Carried in Construct
Also Known As
shiST139
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Krishnan et al., 1996)
Mutagen
ethyl methanesulfonate
(Kim and Wu, 1990)
X ray
(Krishnan et al., 1996)
Progenitor genotype
Cytology
Description

Lesion is the same as in shi1.

(Chen et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygous flies generally do not survive.

      (Kim and Wu, 1990)

      Reversible heat induced paralysis.

      (Siddiqi and Benzer, 1976)

      temperature-sensitive temperature of adult paralysis: 29oC temperature of larval paralysis: 29oC temperature causing developmental defects: 29oC

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Siddiqi & Benzer.

      C. Poodry.

      (Krishnan et al., 1996)
      Comments
      Comments

      Results from response to cervical stimulation, intracellular recordings of flight muscles and direct excitability of muscle demonstrate nerve conduction is intact but the evoked response gradually diminishes as the temperature is raised, there appears to be a defect at the neuromuscular junction.

      (Siddiqi and Benzer, 1976)

      Order of temperature sensitivity in the hemizygous condition: shi4 > shi21 > shi1 > shi2. Order of temperature sensitivity in the homozygous condition: shi21 = shi1 > shi4 >= shi2. Order of temperature sensitivity of heteroallelic combinations: shi2/shi21 = shi1/shi21 >= shi4/shi21 > shi1/shi2 = shi1/shi4 >> shi2/shi4.

      (Kim and Wu, 1990)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      shi12.12H
      (Krishnan et al., 1996)
      shi12.18H
      shi21
      shiST139
      (Chen et al., 2002, Kim and Wu, 1990, Siddiqi and Benzer, 1976)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0082268
      References (4)