Translocation breakpoint is at map position +33.4 to +34.9.
Flies show a typical Sh mutant leg shaking phenotype. Hemizygous males show a reduced preference for sucrose compared to wild-type in feeding preference tests, probably due to a shift in the threshold of detection. The response of flies to 100mM NaCl is not significantly different to wild-type. Flies show an increased tolerance to 0.5M NaCl and 0.2M KCl compared to wild-type, due to an increase in the threshold of repulsion.
Shaking phenotype: muscles manifest a residual K+ current and have a defective action potential from the CGF interneuron.
abnormal leg shaking under ether anesthesia; abnormal A-type potassium currents in larval muscle and/or pupal flight muscle; abnormal action potentials in the adult cervical giant fiber
Merriam and colleagues.
The severity of the sucrose preference defect shows the following order: Sh8 > Sh5 = Sh7 > Sh25 > T(1;Y)V7 > Sh14. The degree of tolerance to 0.5M NaCl shows the order: Sh8 > Sh7 = Sh5 > T(1;Y)V7 = Sh25 > Sh14. The degree of tolerance to 0.2M KCl shows the order: Sh8 = Sh7 = Sh14 > T(1;Y)V7 > Sh5.