FB2024_03 , released June 25, 2024
Allele: Dmel\rtv11
Open Close
General Information
Symbol
Dmel\rtv11
Species
D. melanogaster
Name
FlyBase ID
FBal0014829
Feature type
allele
Associated gene
Dmel\rtv
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Ostrowski et al., 2002)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Nucleotide substitution: T?A.

(Moussian et al., 2005)

Amino acid replacement: L6term.

(Moussian et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:11,153,658..11,153,658 [-]
Nucleotide change:

T11153658A

Amino acid change:

L7term | rtv-PA; L7term | rtv-PB; L7term | rtv-PD

Reported amino acid change:

L6term

Comment:

Reported as a mutation from TTA (Leu) to TAA (stop).

(Moussian et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      At stage 16, the dorsal trunk of the tracheal system is enlarged in the mutant embryos compared to wild type and has a convoluted shape. The luminal chitin cable is disorganised in the trachea of mutant embryos.

      (Hijazi et al., 2009)

      At stage 15, the dorsal trunk lumen in rtv11 mutants remains constricted at branch fusions and the tube between fusion junctions becomes excessively overgrown compared to wild-type, exhibiting a cystic-like appearance. Stage 16 rtv11 mutant embryos display irregular tracheal tube shapes, but do not exhibit defects in branch patterning, compared with wild-type embryos. During stage 16, the rtv11 mutant dorsal tube becomes extensively elongated compared with the wild-type trunk. The lumen of the narrower multicellular ganglionic branches is discontinuous in rtv11 mutants at the border of the ventral nerve cord. Lumen expansion from stage 14 to 15 does not involve cell division and relies on coordinated growth of the apical cell surfaces.

      (Moussian et al., 2006)

      Mutant larvae cannot hatch and they die. They are hyperactive and occasionally turn around in the egg case. Mutant larvae appear bloated compared to wild-type larvae in cuticle preparations as the cuticle detaches from the epidermis. The three layers of the larval cuticle are present ultrastructurally, but the epicuticle is discontinuous and frayed and the procuticle is devoid of laminae. The envelope appears unaffected.

      The head skeleton of mutant larvae is strongly sclerotized and its characteristic fibrous structure is missing.

      The tracheae are undulated in mutant stage 17 embryos compared to wild type and fail to form air-filled tubes.

      (Moussian et al., 2005)

      Homozygous embryos often reverse themselves within the eggshell (8.9% of embryos show this "retroactive" phenotype). When the embryos are mechanically devitellinised the resulting cuticle preparations stretch to a greater extent than wild-type cuticles, resulting in inflated cuticles ("blimp" phenotype). The embryos have defects in the head skeleton and denticle belts.

      (Ostrowski et al., 2002)

      rtv11 embryos have darkly sclerotinised mouthparts, and are sometimes inverted in the egg case.

      (Tearle and Nusslein-Volhard, 1987)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (9)