FB2024_03 , released June 25, 2024
Allele: Dmel\Ge-1EME
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General Information
Symbol
Dmel\Ge-1EME
Species
D. melanogaster
Name
FlyBase ID
FBal0014522
Feature type
allele
Associated gene
Dmel\Ge-1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
(Cao et al., 2016)
Progenitor genotype
Cytology
Description

78bp indel ( 2L:11097925..11098002 ) in the fifth exon of Ge-1, which reduces the length of the serine-rich linker region by 26 amino acid residues.

(Cao et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:11,097,925..11,098,002 [-]
Comment:

A polymorphic deletion of 26 amino acids in the fifth exon reported at genome position 2L:11097925..11098002 (in both Release 5 and Release 6 coordinates).

(Cao et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies carrying the Ge-1EME polymorphism show increased resistance to Sigma virus compared to control flies that do not carry this naturally occurring polymorphism; 10 days after injection with the virus, only 3% of flies carrying Ge-1EME show symptoms of infection, compared to 94% of the control flies.

      (Cao et al., 2016)

      Flies show delayed appearance of the symptom of CO[[2]] sensitivity which is caused by infection with Sigma virus.

      (Gay, 1972)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies carrying the Ge-1EME polymorphism still show increased resistance to Sigma virus compared to control flies that do not carry the polymorphism when the flies are also mutant for AGO251B.

      (Cao et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Slows down multiplication of sigma virus.

      (Gay, 1972)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      EME
      (Cao et al., 2016)
      Ge-1EME
      ref(2)Mm
      Name Synonyms
      Secondary FlyBase IDs
        References (4)