FB2024_03 , released June 25, 2024
Allele: Dmel\perL2
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General Information
Symbol
Dmel\perL2
Species
D. melanogaster
Name
FlyBase ID
FBal0013654
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Nucleotide substitution.

Nucleotide substitution: T3629A.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

T2689032A

Reported nucleotide change:

T3692A

Amino acid change:

V243D | per-PA; V243D | per-PB

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutants have a lengthened rest phase (π). Phase response curves (PRCs) change from a low amplitude, Type 1 to a high amplitude, Type 0 with increased duration of the light pulse. The lengthening of circadian period is a consequence of changes in the time course of the oscillation in the late subjective day.

Long cycle duration, the evening peak of activity is shifted to a later time than wild type.

A long period biological rhythm mutant that does not have learning deficits.

Measures of acquisition at intermediate and maximum levels and of 30 min memory retention are normal. Mean Courtship Index (CI) for males exposed to fertilised females for 30 mins does not differ significantly when exposed to other fertilised females. After 30 mins exposure of an immature male to another immature male a significantly suppressed response to another immature male is observed.

The activity rhythm period of perL2/Y flies is lengthened by CkIIβAnd, by 3.0 hours.

The circadian locomotor activity rhythms of adults exhibit 28-30 hour periodicities at 25oC. At lower temperatures in constant darkness adults exhibited shortened periodicities, at higher temperatures the periodicities were lengthened. In conditions of cycling light (12h light and 12h darkness) the pacemaker can be reset to exhibit 24h rhythmicity and the 'evening peaks' of locomotor activity are in the evening.

Individuals have longer circadian rhythms than wild type. Males show defective courtship conditioning (Jackson, J. Comp. Phys. A 151: 545).

circadian rhythms; long period

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Orr.

Comments
Comments

Dominant female sterility maps to the perL2 chromosome between w and per.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
perL2
perl2
Name Synonyms
Secondary FlyBase IDs
    References (9)