FB2024_03 , released June 25, 2024
Allele: Dmel\otu21
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General Information
Symbol
Dmel\otu21
Species
D. melanogaster
Name
FlyBase ID
FBal0013368
Feature type
allele
Associated gene
Dmel\otu
Associated Insertion(s)
P{}otu21
Carried in Construct
Also Known As
otuP4
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
PM hybrid dysgenesis
P-element activity
(Steinhauer and Kalfayan, 1992)
Progenitor genotype
Associated Insertion(s)
P{}otu21
Cytology
Description

The P elements in otu18, otu19 and otu21 are inserted at exactly the same base position, between 14 and 15bp upstream of the first major transcription start site, designated as +1 in Comer et al., Gene 118: 171-179. The target site duplication GGCTAGAT, located between -14 and -7 is found at both ends of the insertions. Southern analysis revealed the otu21 P insert to be 0.5kb and in the opposite transcriptional orientation to the otu gene.

(Sass et al., 1993)

Insertion of approximately 500bp near the cDNA start site.

(Steinhauer and Kalfayan, 1992)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous females have a differentiated ovary phenotype.

      (Steinhauer and Kalfayan, 1992)

      oncogenic; cystocytes continue dividing and produce tumors

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Mohler.

      Comments
      Comments

      Differentiated class (DIF) of otu alleles.

      (Steinhauer and Kalfayan, 1992)

      DIF class allele.

      (Sass et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      otu21
      otuP4
      (Sass et al., 1993, Steinhauer and Kalfayan, 1992)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)