FB2024_03 , released June 25, 2024
Allele: Dmel\otu12
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General Information
Symbol
Dmel\otu12
Species
D. melanogaster
Name
FlyBase ID
FBal0013359
Feature type
allele
Associated gene
Dmel\otu
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Storto and King, 1987, King et al., 1986)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Spermatogenesis normal but mating behaviour fails because wild type females refuse to react to the courtship attempts of mutant males. Effect is not absolute, and depends on allele (there is a strong correlation between male sterility and severity of impairment in the female phenotype) and varies between affecting 6.7% (otu14) and 86.6% (otu12) of mutant males.

      (Tirronen et al., 1993)

      62% of homozygous ovarioles have quiescent oogonia, and 38% have tumorous oogonia.

      (Storto and King, 1987)

      Quiescent allele; 62% of homozygous ovarioles contain vitellaria that lack developing follicles, 38% are tumour-generating. Hemizygous females do not produce tumorous ovarioles.

      (King et al., 1986)

      quiescent; ovarioles lack germ cells

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Mohler.

      Comments
      Comments

      Quiescent (QUI) class allele. The ovarian phenotype of flies transheterozygous for otu12 and a number of other otu mutations has been analysed.

      (Storto and King, 1987)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      12C-129
      (Mohler and Carroll, 1984)
      fs(1)12C-129
      fs12C-129
      (King et al., 1986)
      otu12
      Name Synonyms
      Secondary FlyBase IDs
        References (4)