FB2024_03 , released June 25, 2024
Allele: Dmel\otu9
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General Information
Symbol
Dmel\otu9
Species
D. melanogaster
Name
FlyBase ID
FBal0013356
Feature type
allele
Associated gene
Dmel\otu
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Oliver et al., 1993)
Mutagen
ethyl methanesulfonate
(Storto and King, 1987, King et al., 1986)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      otu9 homozygous females lay only a few eggs, some of which have a 'crown' of dorsal appendage material, indicating dorsalisation.

      (Goodrich et al., 2004)

      Spermatogenesis normal but mating behaviour fails because wild type females refuse to react to the courtship attempts of mutant males. Effect is not absolute, and depends on allele (there is a strong correlation between male sterility and severity of impairment in the female phenotype) and varies between affecting 6.7% (otu14) and 86.6% (otu12) of mutant males.

      (Tirronen et al., 1993)

      42% of homozygous ovarioles have tumorous oogonia, 39% produce pseudonurse cell chambers with no oocyte, and 13% produce nurse cell/oocyte syncytia. otu9/otu11 female flies are poorly fertile.

      (Storto and King, 1987)

      Differentiated allele; over half of homozygous ovarioles contain differentiated cystocytes (forming pseudonurse cells, nurse cells or oocytes), a substantial number of tumorous ovarioles are also produced. 67% of hemizygous ovarioles are tumorous.

      (King et al., 1986)

      differentiated; ovarian chambers with pseudonurse cells or nurse cell/oocyte synctia

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Mohler.

      Comments
      Comments

      Differentiated (DIF) class allele. The ovarian phenotype of flies transheterozygous for otu9 and a number of other otu mutations has been analysed.

      (Storto and King, 1987)

      Shows a dominant interaction with ovoD2 and ovoD3 : more extreme mutant phenotype as assayed by reduction in number of egg chambers at stage 10 or further developed. There is no apparent correlation with strength of otu allele and its interaction with the ovo alleles.

      (Pauli et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      12-3266
      (Mohler and Carroll, 1984)
      fs(1)12-3266
      fs12-3266
      (King et al., 1986)
      otu9
      Name Synonyms
      Secondary FlyBase IDs
        References (7)