FB2024_03 , released June 25, 2024
Allele: Dmel\ninaA2
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General Information
Symbol
Dmel\ninaA2
Species
D. melanogaster
Name
FlyBase ID
FBal0012960
Feature type
allele
Associated gene
Dmel\ninaA
Associated Insertion(s)
Carried in Construct
Also Known As
ninaAP263
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Schneuwly et al., 1989)
Mutagen
ethyl methanesulfonate
(Schneuwly et al., 1989)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C692T.

(Schneuwly et al., 1989)

Amino acid replacement: Q87term.

(Schneuwly et al., 1989)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:877,620..877,620 [+]
Nucleotide change:

C877620T

Reported nucleotide change:

C693T

Amino acid change:

Q87term | ninaA-PA

Reported amino acid change:

Q87term

(Schneuwly et al., 1989)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous flies and mosaic flies in which the retinal tissue is homozygous for ninaA2 but the rest of the animal is ninaA+ lack the prolonged depolarising afterpotential (PDA) in the electroretinogram response.

      (Gu et al., 2004)

      Mutants exhibit excessive endoplasmic reticulum (ER) in photoreceptor cells that is dependent on expression of rhodopsin gene. The ninaE+/ninaED1 or the ninaE+/ninaED2 heterozygous genotypes do not prevent the accumulation of ER present in ninaA2 flies.

      (Kurada and O'Tousa, 1995)

      With respect to defective PDA, ninaA2 > ninaA1 > ninaA3.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Pak.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (10)