FB2024_03 , released June 25, 2024
Allele: Dmel\mus207A1
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General Information
Symbol
Dmel\mus207A1
Species
D. melanogaster
Name
FlyBase ID
FBal0012628
Feature type
allele
Associated gene
mus207
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Smith and Dusenbery, 1988, Snyder and Smith, 1982)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Exposure of mus207A1 mutant larvae to DDVP for 48 hours results in a significant increase in the migration of DNA in midgut cells at 0.15, 1.5 and 15ng/ml concentrations of DDVP as compared to controls.

      (Mishra et al., 2014)

      mus207A1 mutants have an increased frequency of single-strand annealing repair (SSA) compared to controls in a P{wIw.FRT} hemizygous assay to study DNA double-stranded break repair when assayed at 38oC, but a similar similar SSA frequency to controls when assayed at 32oC.

      (Wei and Rong, 2007)

      Larval survival hypersensitive to exposure to methyl methanesulfonate, nitrogen mustard and ultraviolet light; weakly sensitive to formaldehyde and X rays. Hypermutability to alkylating agents; defective in alkylation repair pathway. Fecundity of homozygous females normal.

      (Smith and Dusenbery, 1988)

      Homozygous larvae are sensitive to UV light, nitrogen mustard and methyl methanesulfonate, but not to X rays or formaldehyde.

      (Snyder and Smith, 1982)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Recovered as a methyl methanesulfonate sensitive mutant.

      (Snyder and Smith, 1982)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mus207A1
      (Mishra et al., 2014, Wei and Rong, 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)