FB2024_03 , released June 25, 2024
Allele: Dmel\mfs(2)3501
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General Information
Symbol
Dmel\mfs(2)3501
Species
D. melanogaster
Name
FlyBase ID
FBal0012231
Feature type
allele
Associated gene
mfs(2)350
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
(Fukunaga, 1980)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous females are essentially completely sterile. Fertility can be recovered in homozygous females by the substitution of cytoplasm by outcrossing. The mfs(2)3501 mutation exerts its effect (producing sterility) only in the presence of cytoplasm from the "350" line in which the mutation was originally isolated. Homozygous males are sterile. Fertility can also be recovered by the substitution of cytoplasm by outcrossing. Homozygous females that are fertile due to the cytoplasmic constitution have normal ovaries with mature eggs and homozygous males that are fertile due to the cytoplasmic constitution have normal testes filled with bundles of spermatozoa and motile sperm. Homozygous females that are sterile due to the cytoplasmic constitution have rudimentary ovaries with no mature eggs. Homozygous sterile males generally have rudimentary testes with no bundles of spermatozoa or motile sperm, but some have normal-sized testes, which in most cases have bundles of spermatozoa but no motile sperm.

      (Fukunaga, 1980)

      male-sterile female-sterile

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Isolated from: Kofu, Japan population, 1971. Separable from: mle1. Recovered as the "350" second chromosome which carries both mfs(2)3501 and mle1.

      (Fukunaga, 1980)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mfs(2)3501
      str(2)350
      (Fukunaga, 1980)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)