FB2024_03 , released June 25, 2024
Allele: Dmel\mei-412
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General Information
Symbol
Dmel\mei-412
Species
D. melanogaster
Name
FlyBase ID
FBal0012151
Feature type
allele
Associated gene
Dmel\mei-41
Associated Insertion(s)
Carried in Construct
Also Known As
mei-41195
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In

        mitosis & nuclear chromosome

        (Gatti, 1979)
        Detailed Description
        Statement
        Reference

        Exposure of mus207A1 mutant larvae to DDVP for 48 hours results in a significant increase in the migration of DNA in midgut cells at 1.5 and 15ng/ml concentrations of DDVP as compared to controls.

        (Mishra et al., 2014)

        The formation of mobile nucleoli is enhanced in these post-replicative repair mutants.

        (Semenov, 1998)

        Defect in a cell cycle checkpoint so that cells with damaged DNA (for example by X ray) are allowed to enter mitotic metaphase.

        (Hari et al., 1995)

        Reduces meiotic exchange.

        (Carpenter and Baker, 1982)

        Homozygotes and hemizygotes show a higher frequency of spontaneous chromosome aberrations in neuroblast metaphases than wild-type larvae. The ratio of chromatid breaks to isochromatid breaks is 1.5-1.6. Approximately half of the breaks are heterochromatic and half are euchromatic. The breaks appear to be randomly distributed among the chromosomes. Breaks are 1.4-1.6 times more frequent in females than in males.

        (Gatti, 1979)

        Strongly reduces meiotic exchange.

        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (2)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (5)
        Reported As
        Symbol Synonym
        41195
        (Gatti, 1979)
        dATR2
        (Barrio et al., 2023)
        mei-41195
        (Semenov, 1998, Hari et al., 1995, Carpenter and Baker, 1982)
        mei-412
        (Mishra et al., 2014)
        mei41195
        (Ahmad and Golic, 1999)
        Name Synonyms
        Secondary FlyBase IDs
          References (9)