FlyBase Allele Report: Dmel\lab[4]

General Information

Symbol

Dmel\lab⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0011517

Feature type

allele

Associated gene

Dmel\lab

Associated Insertion(s)

Carried in Construct

Also Known As

lab^f8

Key Links

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Chouinard and Kaufman, 1991, Merrill et al., 1989)

loss of function allele

Mutagen

ethyl methanesulfonate

(Merrill et al., 1989)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Merrill et al., 1989)

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

In lab⁴ mutant clones in the anterior head, vibrissae are disrupted or missing, the ventral edge of the eye is deleted, and maxillary palps are missing. In posterior head clones, novel bristles appear in the postgena.

(Stultz et al., 2012)

The average number of crystal cells per embryo is reduced in homozygous stage 13-14 embryos compared to wild type.

(Milchanowski et al., 2004)

No salivary gland defects.

(Panzer et al., 1992)

No change in the spatial distribution of ae mRNA.

(Roder et al., 1992)

Hemizygous animals die at the embryonic/first larval instar border. A variable cuticle phenotype is seen, with the severity of the defects correlating with the degree of failure of head involution. The frontal sac appears collapsed, and the pharynx occupies a more anterior position than normal. The salivary glands are missing. Homozygous mutant clones in the head have a mutant phenotype - novel tissue is seen in the postgena and other structures are disrupted.

(Merrill et al., 1989)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions