FB2024_03 , released June 25, 2024
Allele: Dmel\l(1)dh21
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General Information
Symbol
Dmel\l(1)dh21
Species
D. melanogaster
Name
FlyBase ID
FBal0007461
Feature type
allele
Associated gene
l(1)dh2
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Some imaginal discs of homozygous larvae are missing, others are normal. Defects in the cell cycle: few or no dividing cells, affects chromosome condensation, arrest of the cell cycle at metaphase and cell division failures that result in highly polyploid cells.

      (Gatti and Baker, 1989)

      pupal lethal leg discs degenerated; remaining imaginal discs of normal size and structure. Chromosomes in larval ganglion cells irregularly condensed, often displaying coiled and banded appearance; in addition, chromatid breaks and extremely hyperploid or tetraploid cells are frequently observed (Gatti, Pimpinelli, Bove, Baker, Smith, Carpenter and Ripoll, 1984 ; Gatti and Baker, 1989).

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Maternal germline clonal analysis demonstrates there is no maternal effect.

      (Perrimon et al., 1989)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      d-het2
      (Perrimon et al., 1989)
      l(1)dh21
      Name Synonyms
      Secondary FlyBase IDs
        References (2)