FB2024_03 , released June 25, 2024
Allele: Dmel\Kr25
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General Information
Symbol
Dmel\Kr25
Species
D. melanogaster
Name
FlyBase ID
FBal0005810
Feature type
allele
Associated gene
Dmel\Kr
Associated Insertion(s)
Carried in Construct
Also Known As
KrX
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Carrera et al., 1998, Tearle and Nusslein-Volhard, 1987, Preiss et al., 1985)
Progenitor genotype
KrIf-1
(Carrera et al., 1998, Preiss et al., 1985)
Cytology

Polytene chromosomes normal.

(Preiss et al., 1985)
Description

Amino acid replacement: Y233N. Nucleotide substitution: T to A.

(Carrera et al., 1998)

Amino acid replacement: Y233N. Y233N maps to the first zinc finger.

(Jäckle et al., 1988)

tyr --> asn (Gaul, Redemann and Jackle, 1989)

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:25,228,021..25,228,021 [+]
Nucleotide change:

T25228021A

Reported nucleotide change:

T?A

Amino acid change:

Y233N | Kr-PA; Y233N | Kr-PB

Reported amino acid change:

Y233N

(Carrera et al., 1998, Gaul et al., 1989, Jäckle et al., 1988)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygotes have eye defects. Homozygous embryos have segmentation defects.

      (Carrera et al., 1998)

      Weak segmentation phenotype. The Malpighian tubule phenotype is variable in homozygous embryos. In most embryos the Malpighian tubules are shorter than normal (the posterior tubules are longer than the anterior tubules), with irregular buds. Sometimes there are short thickened buds. The ureter is more or less normal.

      (Harbecke and Janning, 1989)

      Segments T2 through A3 are deleted in homozygous embryos.

      (Jäckle et al., 1988)

      Weak allele. Segments T2, T3, A1, A2 and A3 are deleted.

      (Preiss et al., 1985)

      weak allele segments T2 and 3 and A1 deleted; A2-4 variably deleted; Malpighian tubules variable

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Krunspecified

      (Carrera et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Revertant \partial.

      (Carrera et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      IfR2
      (Carrera et al., 1998)
      Kr25
      KrX
      (Harbecke and Janning, 1989, Jäckle et al., 1988, Tearle and Nusslein-Volhard, 1987)
      KrX
      (Skaer, 1993, Preiss et al., 1985)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)