FlyBase Allele Report: Dmel\dsx[23]

General Information

Symbol

Dmel\dsx²³

Species

D. melanogaster

Name

FlyBase ID

FBal0003176

Feature type

allele

Associated gene

Dmel\dsx

Associated Insertion(s)

Carried in Construct

Also Known As

dsx^d+r3

Key Links

Allele class

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

loss of function allele

(Taylor et al., 1994)

Mutagen

X ray

(Baker et al., 1991, Baker and Wolfner, 1988)

Progenitor genotype

dsx^D

(Baker et al., 1991, Baker and Wolfner, 1988, Duncan and Kaufman, 1975)

Caused by aberration

In(3R)dsx²³

Cytology

Description

Produces a shortened transcript.

(An and Wensink, 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal courtship behavior | male | recessive

(Villella and Hall, 1996)

abnormal neuroanatomy

(Billeter et al., 2006)

abnormal neuroanatomy | female (with Df(3R)dsx15)

(Kimura et al., 2008)

Phenotype Manifest In

adult fruitless pMP-e (female) neuron | ectopic | female (with Df(3R)dsx15)

(Kimura et al., 2008)

eye

(Duncan and Kaufman, 1975)

female genital disc (with Df(3R)dsx15)

(Keisman and Baker, 2001)

gonad | embryonic stage (with dsx¹)

(DeFalco et al., 2004)

gonadal sheath proper primordium | female (with dsx¹)

(DeFalco et al., 2003)

hub cell (with dsx¹)

(Le Bras and Van Doren, 2006)

leg

(Duncan and Kaufman, 1975)

serotonergic neuron

(Billeter et al., 2006)

Detailed Description

Statement

Reference

P1 neurons are present in both XX and XY dsx²³/Df(3R)dsx15 animals (these neurons are normally only found in male brains in the wild type).

(Kimura et al., 2008)

dsx²³ mutants appear intersexual externally. Mutant males exhibit a decrease in male-specific serotonergic neurons, while females display ectopic serotonergic neurons. These neurons are differentially patterned depending on the sex of the mutant. In dsx²³ females, a single cluster of three to four serotonergic neurons develops either ventrally or dorsally. In males, both clusters develop but contain 50% fewer neurons than wild-type males.

(Billeter et al., 2006)

dsx¹/dsx²³ mutant gonads are masculinised with respect to hub formation (germline stem cell niche formation).

(Le Bras and Van Doren, 2006)

dsx¹/dsx²³ mutant embryonic gonads appear fully masculinised.

(DeFalco et al., 2004)

In the somatic gonad, stage 15 male dsx¹/dsx²³ mutant embryos are indistinguishable from wild-type males. In contrast, the gonads of stage 15 female dsx¹/dsx²³ mutant embryos exhibit a completely masculinized phenotype, in which male-specific somatic gonadal precursors are clearly present.

(DeFalco et al., 2003)

Both the male and female genital primordia develop in XX genital discs.

(Keisman and Baker, 2001)

XY males show courtship sluggishness when compared to wild type siblings. Aging does not improve the courtship performance. Song pulses are similar to those of dsx⁺ males, though number and duration of song bouts are much reduced. No sine-song bouts whatsoever are generated by dsx mutants. In elicitation and rejection tests, dsx haplo-X mutants demonstrate an attractiveness that cannot be explained by general enfeeblement, such as inability to reject courtship advances.

(Villella and Hall, 1996)

XX dsx²³/Df(3R)dsx15 flies do not show any male-specific courtship when paired with mature virgin females. 100% of XY dsx²³/Df(3R)dsx15 flies show male-specific courtship when paired with mature virgin females. XY dsx²³/Df(3R)dsx15 flies have a reduced courtship index (compared to control males) when paired with immature male flies. XY dsx²³/Df(3R)dsx15 flies have an essentially normal courtship song compared to control XY flies.

(Taylor et al., 1994)

Sex specific neuroblasts fail to undergo any postembryonic divisions in male or female larval nervous systems.

(Taylor and Truman, 1992)

Dorsal musculature does not undergo sexual transformation.

(Taylor, 1992)

When crossed to Df(3R)dsx2D progeny are viable and display the dsx phenotype.

(Baker et al., 1991)

Homozygotes are intersexual. Adults have roughened eyes and deformed legs.

(Duncan and Kaufman, 1975)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

1849

In(3R)dsx²³, dsx²³ Ubx^bx-1 sr¹ e^s/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

Revertant.

Comments

Rank order for subnormal courtship in dsx alleles is dsx¹ < dsx¹⁶ < dsx¹⁵ < dsx²³.

(Villella and Hall, 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

dsx²³

(Kimura et al., 2008, Billeter et al., 2006, Le Bras and Van Doren, 2006, Lee et al., 2006)

dsx^D+R3

(Sanders and Arbeitman, 2008, Keisman and Baker, 2001, Cann et al., 2000, An and Wensink, 1995, Baker et al., 1991, Baker and Wolfner, 1988, Duncan and Kaufman, 1975)

dsx^d+R3

(Lebo et al., 2009)

dsx^d+r3

(Lebo et al., 2009, Arbeitman et al., 2004, Piano et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (21)

Report Sections

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