FlyBase Allele Report: Dmel\dpp[H37]

General Information

Symbol

Dmel\dpp^H37

Species

D. melanogaster

Name

FlyBase ID

FBal0003057

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Also Known As

dpp^Hin37, dpp³⁷

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Irish and Gelbart, 1987)

loss of function allele

(Ray et al., 1991)

Mutagen

X ray

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Irish and Gelbart, 1987)

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage

(St. Johnston et al., 1990)

lethal - all die during embryonic stage | dominant

(Irish and Gelbart, 1987)

some die during embryonic stage

(St. Johnston et al., 1990)

some die during embryonic stage | dominant

(Irish and Gelbart, 1987)

Phenotype Manifest In

amnioserosa

(Leptin et al., 1992)

embryonic epidermis | dorsal

(St. Johnston et al., 1990, Irish and Gelbart, 1987)

Detailed Description

Statement

Reference

dpp^H37/Df(2L)DTD2 embryos fail to form an amnioserosa.

(Leptin et al., 1992)

Ventralized embryos: rings or patches of ventral denticles along dorsoventral axis. Disruption of germ band extension that leads to the invagination of posterior segments into the interior of the embryo.

(Ray et al., 1991)

Fail to complete germ band extension, die with strong ventralized phenotype and no dorsal derived epidermis.

(St. Johnston et al., 1990)

Homozygotes have a ventralized embryonic phenotype: normally ventral epidermal pattern elements are present ventrally and dorsally.

(Irish and Gelbart, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Mutant phenotype rescued by P element mediated transformation of a wild type copy of dpp.

(Hoffmann and Goodman, 1987)

Allele class: Hin

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

dpp³⁷

(Kusch and Reuter, 1999, Jackson and Hoffmann, 1994)

dpp^H37

dpp^Hin37

(Deignan et al., 2016, Miles et al., 2008, Wharton et al., 2004, Ashe et al., 2000, Ashe and Levine, 1999, Rusch and Levine, 1997, Tatei et al., 1995, Leptin et al., 1992, St. Johnston et al., 1990, Hoffmann and Goodman, 1987, Irish and Gelbart, 1987)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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