FB2024_02 , released April 23, 2024
Allele: Dmel\cn1
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General Information
Symbol
Dmel\cn1
Species
D. melanogaster
Name
FlyBase ID
FBal0001731
Feature type
allele
Associated gene
Dmel\cn
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Warren et al., 1996)
natural population
(FlyBase Curators, 2002-)
Progenitor genotype
Cytology
Description

Known mutation in sequenced strain: deletion (removes carboxy end) (see FBrf0097723, FBrf0132132).

(FlyBase Curators, 2002-)

Deletion of approximately 1.8kb.

(Levis, 2000.11.20)

1.5kb deletion.

(Warren et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  neurodegenerative disease
      modeled by st1
      (Cunningham et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cn1 mutant adults show a significant and progressive decrease in climbing ability, as compared to controls. However, 21-days old mutant adults raised at 29[o]C do not show significantly changes in PPL1 neurons, as compared to age-matched controls.

      (Cunningham et al., 2018)

      Ocelli are unpigmented.

      (Tearle, 1991)

      Eye colour: bright red; similar to v and st. Ocellus colour: colourless. RK1.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      cn1 has abnormal locomotor behavior | adult stage | progressive phenotype, non-enhanceable by st1

      (Cunningham et al., 2018)
      NOT Enhancer of
      Statement
      Reference

      cn1 is a non-enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of st1

      (Cunningham et al., 2018)

      cn1 is a non-enhancer of short lived phenotype of st1

      (Cunningham et al., 2018)
      Suppressor of
      Statement
      Reference

      cn1 is a suppressor of decreased cell number | adult stage | progressive | heat sensitive phenotype of st1

      (Cunningham et al., 2018)
      NOT Suppressor of
      Statement
      Reference

      cn[+]/cn1 is a non-suppressor of lethal phenotype of Cam7/Camn339

      (Wang et al., 2003)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      cn1 has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      NOT Enhancer of
      Statement
      Reference

      cn[+]/cn1 is a non-enhancer of adult head phenotype of Cam7/Camn339

      (Wang et al., 2003)

      cn[+]/cn1 is a non-enhancer of pupa phenotype of Cam7/Camn339

      (Wang et al., 2003)
      Suppressor of
      Statement
      Reference

      cn1 is a suppressor of dopaminergic PPL1 neuron | progressive | heat sensitive phenotype of st1

      (Cunningham et al., 2018)
      NOT Suppressor of
      Statement
      Reference

      cn[+]/cn1 is a non-suppressor of adult head phenotype of Cam7/Camn339

      (Wang et al., 2003)

      cn[+]/cn1 is a non-suppressor of pupa phenotype of Cam7/Camn339

      (Wang et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (2)
      Stocks (2,760)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Marker mutation present in the strain used in the genome sequencing project.

      (Misra et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      References (34)