FlyBase Allele Report: Dmel\bs[2]

General Information

Symbol

Dmel\bs²

Species

D. melanogaster

Name

FlyBase ID

FBal0001305

Feature type

allele

Associated gene

Dmel\bs

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory | adult stage (with bs¹³⁴⁸)

(Thran et al., 2013)

abnormal memory | adult stage | dominant

(Thran et al., 2013)

viable (with bs⁰³²⁶⁷)

(Roch et al., 1998)

visible

(Rendina et al., 2010)

visible (with bs⁰³²⁶⁷)

(Roch et al., 1998)

visible | recessive

(Baonza and Garcia-Bellido, 1999)

Phenotype Manifest In

wing

wing (with bs⁰³²⁶⁷)

(Roch et al., 1998)

wing vein

(Sturtevant and Bier, 1995)

wing vein | ectopic

(Rendina et al., 2010, Terriente-Félix and de Celis, 2009, Marenda et al., 2004, Baonza and Garcia-Bellido, 1999)

wing vein | ectopic (with bs⁰³²⁶⁷)

(Roch et al., 1998)

Detailed Description

Statement

Reference

Heterozygous bs² mutant flies show a significant loss of visual orientation memory.

Transheterozygous bs²/bs¹³⁴⁸ mutant flies show a significant loss of visual orientation memory.

(Thran et al., 2013)

Homozygous flies have ectopic wing vein tissue.

(Rendina et al., 2010)

bs² and bs²/In(2LR)Px⁴ mutants do not increase sleep after social enrichment.

Circadian rhythms are intact in bs² mutants.

(Donlea et al., 2009)

Homozygous bs² mutant wings show ectopic wing vein tissue in the distal regions of the L3, L4 and most L5 veins.

(Terriente-Félix and de Celis, 2009)

Wings from bs² heterozygotes are normal.

(Lyulcheva et al., 2008)

Homozygotes have extra wing veins.

(Baonza and Garcia-Bellido, 1999)

bs⁰³²⁶⁷/bs² is a viable combination that displays almost entirely wing vein tissue in the wing.

(Roch et al., 1998)

Extra vein mutation.

(Sturtevant and Bier, 1995)

More extreme allele than bs¹. RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

bs² has visible phenotype, enhanceable by Bap170^hfl1/Bap170[+]

(Rendina et al., 2010)

bs² has visible | recessive phenotype, enhanceable by emc¹/emc¹¹

(Baonza and Garcia-Bellido, 1999)

Enhancer of

Statement

Reference

bs[+]/bs² is an enhancer of visible phenotype of if³

(Wessendorf et al., 1992)

Suppressor of

Statement

Reference

bs[+]/bs² is a suppressor of visible phenotype of LIMK1^UAS.cCa, Scer\GAL4^en-e16E

(Chen et al., 2004)

bs² is a suppressor of visible phenotype of csw^lf

(Firth et al., 2000)

bs⁰³²⁶⁷/bs² is a suppressor of visible phenotype of rho⁹/rho^ve-1, vn^M2/vn¹

(Roch et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

bs² has wing vein | ectopic phenotype, enhanceable by Bap170^hfl1/Bap170[+]

(Rendina et al., 2010)

bs² has wing vein | ectopic phenotype, enhanceable by osa^C819/Scer\GAL4^MD-638

(Terriente-Félix and de Celis, 2009)

bs² has wing vein | ectopic phenotype, enhanceable by emc¹/emc¹¹

(Baonza and Garcia-Bellido, 1999)

Suppressed by

Statement

Reference

bs² has wing vein | ectopic phenotype, suppressible by osa[+]/brm[+]/osa³⁰⁸/brm²

(Terriente-Félix and de Celis, 2009)

bs² has wing vein | ectopic phenotype, suppressible by brm²

(Marenda et al., 2004)

NOT suppressed by

Statement

Reference

bs² has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

bs[+]/bs² is an enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

bs² is an enhancer of wing vein | ectopic phenotype of rho^hs.PSt

(Sturtevant and Bier, 1995)

bs[+]/bs² is an enhancer of wing phenotype of if³

(Wessendorf et al., 1992)

Suppressor of

Statement

Reference

bs[+]/bs² is a suppressor of wing phenotype of Scer\GAL4^Bx-MS1096, pico^{UAS.Tag:polyHis,Tag:MYC}

(Lyulcheva et al., 2008)

bs[+]/bs² is a suppressor of wing phenotype of LIMK1^UAS.cCa, Scer\GAL4^en-e16E

(Chen et al., 2004)

bs² is a suppressor of wing vein phenotype of csw^lf

(Firth et al., 2000)

bs⁰³²⁶⁷/bs² is a suppressor of wing vein phenotype of rho⁹/rho^ve-1, vn^M2/vn¹

(Roch et al., 1998)

bs² is a suppressor of wing vein phenotype of rho^ve-1

(Sturtevant and Bier, 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Bap170^hfl1/+ enhances the ectopic wing vein phenotype of bs² homozygotes.

(Rendina et al., 2010)

The ectopic wing vein phenotype observed in homozygous bs² mutant wings is suppressed in animals doubly heterozygous for osa³⁰⁸ and brm².

Overexpression of osa^C819 by Scer\GAL4^MD-638 enhances the ectopic veins observed in bs² mutant animals.

(Terriente-Félix and de Celis, 2009)

bs²/+ suppresses the mutant wing phenotype caused by expression of LIMK1^Scer\UAS.cCa under the control of Scer\GAL4^en-e16E (the % of wings with normal morphology at 18^oC is increased from 9% to 81%).

(Chen et al., 2004)

The bs² extra wing vein phenotype is enhanced by emc¹/emc¹¹. emc¹ clones in bs² wings differentiate as vein everywhere in the wing blade covering intervein regions as vein.

(Baonza and Garcia-Bellido, 1999)

bs⁰³²⁶⁷/bs²; rho⁹, vn^M2/rho^ve-1, vn¹ triple mutants show an almost wild type wing vein pattern.

(Roch et al., 1998)

Enhancement of rho^hs.PSt ectopic vein phenotype and suppression of the rho^ve-1 loss of vein phenotype.

(Sturtevant and Bier, 1995)

Enhances the wing blister phenotype of if³ flies.

(Wessendorf et al., 1992)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

bs² is rescued by Scer\GAL4^c105/bs^UAS.cHa

(Thran et al., 2013)

bs² is rescued by Scer\GAL4^EB1/bs^UAS.cHa

(Thran et al., 2013)

bs² is rescued by Scer\GAL4^Alp4-c232/bs^UAS.cHa

(Thran et al., 2013)

Comments

Expression of bs^Scer\UAS.cHa in ring neurons under the control of any of Scer\GAL4^c105 (R1), Scer\GAL4^EB1 (R2) or Scer\GAL4^Aph-4-c232 (R3/R4d) rescues the visual orientation memory defects seen in heterozygous bs² mutants. Expressing bs^Scer\UAS.cHa under the control of Scer\GAL4^ftz.ng (R4) in bs² mutant flies leads to general locomotor and orientation defects so these flies could not be tested for visual orientation memory phenotype defects.

(Thran et al., 2013)

Images (1)

Holtzman, S. and Kaufman, T. (2013)

Mutant

Wild-type

Stocks (2)

403

105894

Notes on Origin

Discoverer

Bridges, 24 Nov. 1925.

Comments

bs²/Df(2R)Px1 easily separable from +/Df(2R)Px1, especially at or below 19^oC.

Wing phenotype caused by same mechanism as that of px.

(Waddington, 1940)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Srf²

(Faria et al., 2023)

bs²

(Faria et al., 2023, Thran et al., 2013, Rendina et al., 2010, Donlea et al., 2009, Terriente-Félix and de Celis, 2009, Lyulcheva et al., 2008, Pesin and Orr-Weaver, 2007, Janody and Treisman, 2006)

Name Synonyms

Secondary FlyBase IDs

References (17)

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