FlyBase Allele Report: Dmel\bam[1]

General Information

Symbol

Dmel\bam¹

Species

D. melanogaster

Name

FlyBase ID

FBal0001017

Feature type

allele

Associated gene

Dmel\bam

Associated Insertion(s)

P{hsneo}bam¹

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(McKearin and Spradling, 1990)

Progenitor genotype

Associated Insertion(s)

P{hsneo}bam¹

Cytology

Description

P{hsneo} insertion.

(McKearin and Spradling, 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:25,245,111..25,245,111 [+]

(Monteiro et al., 2023, Spradling et al., 1999, McKearin and Spradling, 1990)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(McKearin and Spradling, 1990)

female sterile | recessive

(Spradling et al., 1999)

increased cell number (with bam^Δ86)

(Insco et al., 2009)

increased occurrence of cell division | adult stage | male (with bam^Δ86)

(Insco et al., 2009)

male sterile

(McKearin and Spradling, 1990)

neoplasia | spermatogenesis (with bam^114-97)

(Feng et al., 2017)

Phenotype Manifest In

egg chamber

(Lin et al., 1994, McKearin and Spradling, 1990)

fusome

(Lin et al., 1994)

germline cell | female

(Lin et al., 1994)

ovary

(McKearin and Spradling, 1990)

spermatogonial cyst (with bam^Δ86)

(Insco et al., 2009)

spermatogonium | increased number (with bam^Δ86)

(Kim et al., 2017)

testis

(McKearin and Spradling, 1990)

Detailed Description

Statement

Reference

bam¹/bam^114-97 testes show a germline stem cell-like tumor phenotype, although cells do not show signs of cyst-cell mis-differentiation (i.e. not Zfh-1-positive).

(Feng et al., 2017)

bam¹/bam^Δ86 mutant testes contain large number of over-proliferating spermatogonia.

(Kim et al., 2017)

bam¹/bam^Δ86 mutant testes show large germline cysts containing 32 or more cells undergoing S-phase, some located far from the testis tip, indicating that more than the usual 4 rounds of transit amplification has occurred.

(Insco et al., 2009)

Analysis of mutant females reveals cyst development is arrested at an early stage. Cells contain very small fusomes associated with a single ring canal, though these fusomes appear normal as seen by electron microscopy.

(Lin et al., 1994)

Homozygous females are viable but lay no eggs: disruption of oogenesis during early stages of development. Ovaries contain tumorous egg chambers. Examination of testes suggested that gametogenesis is also disrupted at an early stage in males.

(McKearin and Spradling, 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

bam¹/bam^Δ86 is rescued by bam^hs.PO

(Kim et al., 2017)

bam¹ is rescued by bam^+t2.9

(McKearin and Spradling, 1990)

Not rescued by

bam¹ is not rescued by bam^tMa

(McKearin and Spradling, 1990)

Comments

Heat-shock induced pulse expression of bam^hs.PO restores the production of functional sperm in bam¹/bam^Δ86 mutants.

(Kim et al., 2017)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

bam¹

(Huang et al., 2024, Baker et al., 2023, Monteiro et al., 2023, Berry et al., 2022, Rastegari et al., 2020, Primus et al., 2019, Feng et al., 2017, Kim et al., 2017, Yang et al., 2017, Kao et al., 2015, Tseng et al., 2014, Chang et al., 2013, Insco et al., 2012, Gan et al., 2010, Gan et al., 2010, Insco et al., 2009, Insco et al., 2009)

bam^P

(McKearin and Spradling, 1990)

bam^neo61

fs(3)neo61

(Spradling et al., 1999)

Name Synonyms

Secondary FlyBase IDs

FBal0030552

References (25)

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