FB2024_03 , released June 25, 2024
Allele: Dmel\AdhnB
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General Information
Symbol
Dmel\AdhnB
Species
D. melanogaster
Name
FlyBase ID
FBal0000348
Feature type
allele
Associated gene
Dmel\Adh
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

Mutagen
ethyl methanesulfonate
(Martin et al., 1985)
Progenitor genotype
AdhF
Cytology
Description

Steady state level of Adh mRNA is reduced to 60% of control.

(Brogna, 1999)

TGG Trp codon at amino acid 235 replaced by a TGA termination codon.

(Martin et al., 1985)

UGA codon at 234 suppressible in vitro with yeast ochre suppressor tRNA.

(Kubli et al., 1982)

Amino acid replacement: W235term.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:14,617,181..14,617,181 [+]
Nucleotide change:

G14617181A

Reported nucleotide change:

G?A

Amino acid change:

W236term | Adh-PC; W236term | Adh-PE; W236term | Adh-PF; W236term | Adh-PH; W236term | Adh-PI

Reported amino acid change:

W235term

Comment:

TGG tp TGA

(Martin et al., 1985, Kubli et al., 1982)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      No Assay Recorded
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      adult stage
      (Martin et al., 1985)
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (50)
      Notes on Origin
      Discoverer

      Sofer.

      Induced on: In(2LR)O. Selected as: Pentenol resistant adult.

      Comments
      Comments

      CRM positive.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      AdhnB
      Name Synonyms
      Secondary FlyBase IDs
        References (9)