FlyBase Allele Report: Dmel\ac[Hw-1]

General Information

Symbol

Dmel\ac^Hw-1

Species

D. melanogaster

Name

FlyBase ID

FBal0000167

Feature type

allele

Associated gene

Dmel\ac

Associated Insertion(s)

gypsy{}ac^Hw-1

Carried in Construct

Also Known As

Hw¹, Hw

Key Links

Allele class

gain of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

gain of function allele

(Reddy et al., 1997, Gomez-Skarmeta et al., 1995)

Mutagen

spontaneous

(Campuzano et al., 1986)

Progenitor genotype

Associated Insertion(s)

gypsy{}ac^Hw-1

Caused by aberration

Dp(1;1)Hw

Cytology

Description

gypsy insertion within the ac coding sequences, resulting in a protein truncated 77 amino acids at the C terminus.

(Gomez-Skarmeta et al., 1995)

gypsy insertion in the ac region of the achaete-scute complex.

(Rushlow et al., 1989)

gypsy insert into ac coding region (also a 2.6kb jockey insert into y coding region).

(Campuzano et al., 1986)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

visible

(Usui et al., 2004, Reddy et al., 1997)

visible | dominant

(Cline, 1983)

visible | recessive

(Held, 1990)

Phenotype Manifest In

campaniform sensillum

glial cell | ectopic

(Giangrande, 1995)

macrochaeta & head

macrochaeta & thorax

macrochaeta | ectopic

(Jafar-Nejad et al., 2003, Rushlow et al., 1989)

mesothoracic metatarsus

(Held, 1990)

mesothoracic tarsal bristle

(Held, 1990)

mesothoracic tergum & macrochaeta | ectopic

(Usui et al., 2004)

microchaeta

nerve | ectopic

(Giangrande, 1995)

third segment of antenna

(Reddy et al., 1997)

wing & nerve

(Giangrande, 1995)

wing margin bristle | ectopic

(Badenhorst et al., 2002)

Detailed Description

Statement

Reference

Mutant adults have ectopic macrochaetae on the notum, with the sites of the ectopic bristles clustering at sites devoid of sr expression.

(Usui et al., 2004)

ac^Hw-1 mutant flies exhibit an occasional extra macrochaetae on the notum.

(Jafar-Nejad et al., 2003)

ac^Hw-1/+ animals exhibit about 23 extra bristles per wing.

(Badenhorst et al., 2002)

The number of olfactory sensilla on the surface of the third antennal segment is normal. Large bristles resembling macrochaetae are seen on the surface of the third antennal segment.

(Reddy et al., 1997)

mod(mdg4)^ul causes a partial suppression of the ac^Hw-1 mutant phenotype. Strong su(Hw) mutations have a dominant suppressing effect on ac^Hw-1 in combination with mod(mdg4)^ul, weak su(Hw) mutations acquire properties of strong su(Hw) mutations when in combination with mod(mdg4)^ul.

(Georgiev and Kozycina, 1996)

Glial cell along the anterior margin of the wing are normal, and additional glial cells are present where ectopic nerves develop. The ectopic nerves and glia develop later than the endogenous nerves and glia.

(Giangrande, 1995)

The total number of bristles on the basitarsi of the second legs is increased.

(Held, 1990)

Double mutant ac^Hw-1,h or ac^Hw-1,emc flies augment the derepression of the ac-sc complex. ac^Hw-1 and h, and ac^Hw-1 and emc interact synergistically.

(del Prado and Garcia-Bellido, 1984)

No significant effect of maternal da genotype on Hairy wing phenotypic expression is seen in triploid intersexes. Sxl^M1 reduces Hairy wing phenotypic expression in triploid intersexes.

(Cline, 1983)

Males and heterozygous females have extra bristles on the head (especially occipitals), the notum and the mesopleurae; also extra bristles, including sensory ones and campaniform sensilla (FBrf0037150), along longitudinal veins and in membrane of wing. Homozygous females more extreme; 110 extra chaetae on wing vs. 49.5 for ac^Hw-1/+; 11 on scutellum and postnotum vs. 0.7 in ac^Hw-1/+ (FBrf0023144). Number of extra bristles inversely correlated with temperature (FBrf0021579). ac^Hw-1/ac^Hw-1 females exhibit 40-80% wild-type viability and are agametic steriles; clones of homozygous germinal cells in ac^Hw-1/+ females capable of producing progeny (FBrf0039441); however, Garcia-Alonso and Garcia-Bellido (FBrf0045360) claim that their strain is no longer homozygous female-sterile. Viability and fertility of ac^Hw-1/Y males and ac^Hw-1/+ females good. RK1 as male or heterozygous female.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ac^Hw-1 has visible phenotype, enhanceable by sr¹

(Usui et al., 2004)

Other

Statement

Reference

ac^Hw-1, hry^unspecified, pyd^unspecified has visible | recessive phenotype

(Held, 1990)

Phenotype Manifest In

Enhanced by

Statement

Reference

ac^Hw-1 has mesothoracic tergum & macrochaeta | ectopic phenotype, enhanceable by sr¹

(Usui et al., 2004)

ac^Hw-1 has macrochaeta | ectopic phenotype, enhanceable by Scer\GAL4^sca-537.4/sens^UAS.cNa

(Jafar-Nejad et al., 2003)

ac^Hw-1 has wing margin bristle | ectopic phenotype, enhanceable by Df(3R)awd-KRB/+

(Badenhorst et al., 2002)

ac^Hw-1 has wing margin bristle | ectopic phenotype, enhanceable by ttk[+]/ttk⁰⁰²¹⁹

(Badenhorst et al., 2002)

ac^Hw-1 has wing margin bristle | ectopic phenotype, enhanceable by ttk[+]/ttk^rM730

(Badenhorst et al., 2002)

Suppressed by

Statement

Reference

ac^Hw-1 has macrochaeta | ectopic phenotype, suppressible by hry^hs.P1

(Rushlow et al., 1989)

ac^Hw-1 has phenotype, suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Enhancer of

Statement

Reference

ac^Hw-1 is an enhancer of macrochaeta | ectopic phenotype of Scer\GAL4^sca-537.4, sens^UAS.cNa

(Jafar-Nejad et al., 2003)

Other

Statement

Reference

ac^Hw-1, hry^unspecified, pyd^unspecified has mesothoracic tarsal bristle phenotype

(Held, 1990)

ac^Hw-1, hry^unspecified, pyd^unspecified has mesothoracic metatarsus phenotype

(Held, 1990)

Additional Comments

Genetic Interactions

Statement

Reference

ac^Hw-1 ; sr¹ double mutant flies have a broader distribution of ectopic bristles over the notum than in flies mutant for ac^Hw-1 alone. This effect is synergistic; the double mutant displays more bristles than the sum of the two single mutants.

(Usui et al., 2004)

ac^Hw-1 mutant; sens^Scer\UAS.cNa; Scer\GAL4^sca-537.4 flies have many more extra macrochaetae than the sum of the two genotypes alone.

(Jafar-Nejad et al., 2003)

The addition of ttk^rM730/+ to ac^Hw-1/+ animals leads to an 1.4 enhancement of the ectopic wing margin bristle phenotype. The addition of ttk⁰⁰²¹⁹/+ to ac^Hw-1/+ animals leads to an 1.4 enhancement of the ectopic wing margin bristle phenotype. The addition of Df(3R)awd-KRB/+ to ac^Hw-1/+ animals leads to an 1.4 enhancement of the ectopic wing margin bristle phenotype.

(Badenhorst et al., 2002)

h^unspecified pyd^unspecified ac^Hw-1 triple mutants show synergistic increases in the number of bristles on the basitarsi of the second legs.

(Held, 1990)

Ectopic bristle formation can be rescued by the presence of the h^hs.P1 construct.

(Rushlow et al., 1989)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (17)

Bloomington

109

Df(1)sc10-1, sc^10-1/y¹ ac^Hw-1

6328

y¹ ac^Hw-1 v¹ Polr2A^Ubl/FM7c

60337

y¹ ac^Hw-1 v¹ Polr2A^Ubl/FM7i

6019

Df(1)w258-11, y¹/In(1)dl-49, y¹ ac^Hw-1 m² g⁴

5393

ras¹ v¹ l(1)10Bm¹/In(1)dl-49, ac^Hw-1 m² g⁴

Kyoto

102024

y¹ ac^Hw-1 f^36a / FM6

105739

Df(1)sc10-1, sc^10-1/y¹ ac^Hw-1

102043

y¹ ac^Hw-1 v¹ Polr2A^Ubl / FM7c

106072

Dp(1;1)sc^V1, y¹ ac^Hw-1/C(1)DX, y¹ f¹

102025

y¹ ac^Hw-1 r⁹ /FM7a, y¹ w^a Bar¹

108557

Df(1)w258-11, y¹/In(1)dl-49, y¹ ac^Hw-1 m² g⁴

101908

In(1)dl-49, y¹ ac^Hw-1 m² g⁴ ; T(1;3)sc^Mc, sc^Mc

More stocks available...

Notes on Origin

Discoverer

Bridges, 12th March 1923.

Arose on: y^unspecified.

Comments

"Phenotypic class: female sterile | recessive" was stated as tentative. Many rearrangements with breakpoints in the distal portion of the achaeae-scute complex have a weak ac^Hw-1 effect, especially as indicated by microchaetae on the mesopleurae; duplications for rearranged scute loci have enhanced effects.

ac^Hw-1/ac^Hw-1 and +/- are autonomous in somatic clones until 8 hr before puparium formation; altering cellular genotype after that time is without effect owing to perdurance.

(Garcia-Bellido and Merriam, 1971)

Classifiable in a single dose in triploids.

(Schultz, 1934)

Duplication of ac⁺ without phenotypic effects except that they suppress h¹.

(Botas et al., 1982)

X-ray-induced full and partial revertants are frequently mutant for ac.

(Garcia Alonso and Garcia-Bellido, 1986)

The status of this duplication is unclear. FBrf0004676 claimed it to be a tandem duplication for 1B1--1B2, but molecular analysis by Campuzano et al. (FBrf0043905) did not find any evidence for a duplication.

(Demerec and Hoover, 1939)

The distribution of expressing cells in the wing disk is much less localized than in wild type. Developmental Northern blots show peak accumulations in early embryos and early pupae.

(Balcells et al., 1988)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

(Held, 1990, Cline, 1983)

Hw¹

(Usui et al., 2004, Campos-Ortega, 1998, Reddy et al., 1997, Georgiev and Kozycina, 1996, Giangrande, 1995, Gomez-Skarmeta et al., 1995, Udomkit et al., 1995, Ruiz-Gomez and Ghysen, 1993, Blair et al., 1992, Georgiev, 1990, Mlodzik et al., 1990, Harrison et al., 1989, Rushlow et al., 1989, del Prado and Garcia-Bellido, 1984)

ac^Hw-1

Name Synonyms

Secondary FlyBase IDs

References (30)

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