FB2024_04 , released June 25, 2024
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Citation
Whitford, K.L., Ghosh, A. (2001). Plexin signaling via off-track and rho family GTPases.  Neuron 32(1): 1--3.
FlyBase ID
FBrf0141776
Publication Type
Review
Abstract
Two papers in this issue of Neuron examine new aspects of Semaphorin signaling via Plexin receptors. Winberg et al. present evidence that the transmembrane protein Off-track (OTK) interacts biochemically and genetically with Plexin A and is important for Sema 1a repulsive signaling. Hu et al. examine the coupling of Plexin B to Rac and RhoA and propose that Plexin B signaling involves inhibition of Rac function by direct sequestration and simultaneous activation of RhoA.
PubMed ID
11604131
PubMed Central ID
DOI
10.1016/s0896-6273(01)00459-7
Related Publication(s)
Research paper

The transmembrane protein off-track associates with plexins and functions downstream of semaphorin signaling during axon guidance.
Winberg et al., 2001, Neuron 32(1): 53--62 [FBrf0139778]

Plexin b mediates axon guidance in Drosophila by simultaneously inhibiting active rac and enhancing rhoa signaling.
Hu et al., 2001, Neuron 32(1): 39--51 [FBrf0139777]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Genes (9)