TAF8L, ms(3)sa, tTAF
Please see the JBrowse view of Dmel\sa for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.40
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sa using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: round spermatid
Turns on specifically in male germ cells soon after initiation of spermatocyte differentiation and persists throughout the remainder of the primary spermatocyte stage. Localizes to the nucleolus.
JBrowse - Visual display of RNA-Seq signals
View Dmel\sa in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mutant allele fails to complement a QTL affecting male mating behaviour.
can, mia and sa are required for accumulation of tweT:Ecol\lacZ transgene in late primary spermatocytes.
Wild type function of aly, can, mia and sa is required for cell-cycle progression through the G2/M transition of meiosis I in males and for onset of spermatid differentiation. Mutations in can and sa are epistatic to mutations in twe. The phenotype of these meiotic arrest mutants is strikingly similar to the histopathological features of meiosis I maturation arrest infertility in human males, suggesting that the control point may be conserved from flies to man.
sa is required for both the progression of the male meiotic cell cycle and the onset of postmeiotic differentiation.
Mutations of sa affect the morphology and behaviour of the mitotic spindles of embryonic cleavage divisions to produce multipolar spindles in male meiosis and generate abnormal mitotic figures in larval neuroblasts.
Source for merge of: sa CG11308