FB2024_02 , released April 23, 2024
Gene: Dmel\kl-2
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General Information
Symbol
Dmel\kl-2
Species
D. melanogaster
Name
male fertility factor kl2
Annotation Symbol
CG17866
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001313
Gene Model Status
Current
Stock Availability
2 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

kl2, Lms2

Key Links
Genomic Location
Cytogenetic map
h10-h11
Sequence location
Recombination map
Y-
RefSeq locus
NC_024512 REGION:573088..664173
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR035699
(InterPro Project Members, 2004-)
enables ATP hydrolysis activity
inferred from electronic annotation with InterPro:IPR003593
(InterPro Project Members, 2004-)
enables dynein intermediate chain binding
inferred from electronic annotation with InterPro:IPR026983
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(GO Reference Genome Project, 2011-)
enables dynein light intermediate chain binding
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR026983
(InterPro Project Members, 2004-)
enables minus-end-directed microtubule motor activity
inferred from sequence or structural similarity with UniProtKB:A8JDH8
(Gene Ontology Curators, 2002-)
inferred from electronic annotation with InterPro:IPR026983
(InterPro Project Members, 2004-)
inferred from electronic annotation with InterPro:IPR004273, InterPro:IPR026983
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(GO Reference Genome Project, 2011-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in flagellated sperm motility
inferred from expression pattern
(Zur Lage et al., 2021)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in cilium movement involved in cell motility
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(GO Reference Genome Project, 2011-)
involved_in microtubule-based movement
inferred from electronic annotation with InterPro:IPR026983
(InterPro Project Members, 2004-)
inferred from electronic annotation with InterPro:IPR004273, InterPro:IPR026983
(InterPro Project Members, 2004-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
is_active_in sperm flagellum
inferred from direct assay
(Zur Lage et al., 2021)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in 9+2 motile cilium
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(GO Reference Genome Project, 2011-)
is_active_in axoneme
inferred from biological aspect of ancestor with PANTHER:PTN002472922
(GO Reference Genome Project, 2011-)
part_of dynein complex
traceable author statement
(de Carvalho et al., 2000)
inferred from electronic annotation with InterPro:IPR026983
(InterPro Project Members, 2004-)
inferred from electronic annotation with InterPro:IPR004273, InterPro:IPR026983
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000743491
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
ATP hydrolysis activity
RHEA 13065:
Summaries
Gene Group (FlyBase)
AXONEMAL INNER ARM DYNEIN HEAVY CHAINS -
Dynein heavy chains are minus end-directed microtubule motor proteins. Axonemal dynein complexes interact with adjacent microtubules in the axoneme. Coordinated binding and release of the axonemal dyneins slide the microtubules relative to each other causing the axoneme to bend driving ciliary and flagellar motion. Axonemal inner arm dynein heavy chains are the microtubule-binding motor protein of the dynein inner arm. (Adapted from FBrf0230280).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
kl-2
Males deficient or mutant for kl-2 are sterile; primary ultrastructural lesion not identified. Such sterile males lack a 300-325 kilodalton sperm polypeptide thought to be a structural component of the axoneme (Goldstein, Hardy, and Lindsley, 1982, Proc. Nat. Acad. Sci. USA 79: 7404-09; Hardy, Lindsley, Livak, Lewis, Sivertsen, Joslyn, Edwards, and Bonaccorsi, 1984, Genetics 107: 591-610).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\kl-2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q5LJP0)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 6.01

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
kl-2-RD
FBtr0346722
NM_001015505
13386
4459
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kl-2 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.19

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
is_active_in sperm flagellum
inferred from direct assay
(Zur Lage et al., 2021)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\kl-2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of kl-2
Transgenic constructs containing regulatory region of kl-2
Aberrations (Deficiencies and Duplications) ( 70 )
Inferred from experimentation ( 70 )
Gene disrupted in
Df(YL)A10
(Hazelrigg et al., 1982)
Df(YL)A17
(Hazelrigg et al., 1982)
Df(YL)A49
(Hazelrigg et al., 1982)
Df(YL)B14
(Hazelrigg et al., 1982)
Df(YL)G19
(Hardy et al., 1984)
Df(YL)G20
(Hardy et al., 1984)
Df(YL)G21
(Hardy et al., 1984)
Df(YL)G22
(Hardy et al., 1984)
Df(YL)G23
(Hardy et al., 1984)
Df(YL)G24
(Hardy et al., 1984)
Df(YL)H121
(Bonaccorsi and Lohe, 1991)
Df(YL)S9
(Gatti and Pimpinelli, 1983)
Df(YL)S10
(Gatti and Pimpinelli, 1983)
Df(YL)S11
(Gatti and Pimpinelli, 1983)
Df(YL)S14
(Gatti and Pimpinelli, 1983)
In(YL)S16L
(Gatti and Pimpinelli, 1983)
In(YLS)A33
(Hazelrigg et al., 1982)
In(YLS)S18
(Hardy et al., 1984, Gatti and Pimpinelli, 1983)
T(1;Y)R5
T(1;Y)R19
T(1;Y)V30
T(Y;2)R155
(Hardy et al., 1984, Gatti and Pimpinelli, 1983)
Ts(1Lt;YSt)E15+Ts(YLt;3Lt)W27
Ts(1Lt;YSt)E15
(Zhang and Stankiewicz, 1998)
Ts(1Lt;YSt)F12
(Zhang and Stankiewicz, 1998)
Ts(1Rt;YLt)V24
(Bonaccorsi et al., 1990)
Ts(1Rt;YSt)V8
(Bonaccorsi et al., 1990)
Ts(1Rt;YSt)W19
(Bonaccorsi et al., 1990)
Ts(YLt;3Lt)W27
(Bonaccorsi et al., 1990)
Ts(YSt;4Rt)B15
(Hazelrigg et al., 1982)
Gene not disrupted in
Df(YL)A11
(Hazelrigg et al., 1982)
Df(YL)A32
(Hazelrigg et al., 1982)
Df(YL)A39
(Hazelrigg et al., 1982)
Df(YL)B4
(Hazelrigg et al., 1982)
Df(YL)B12
(Hazelrigg et al., 1982)
Df(YL)S5
(Gatti and Pimpinelli, 1983)
Df(YL)S6
(Gatti and Pimpinelli, 1983)
Df(YL)S7
(Gatti and Pimpinelli, 1983)
Df(YL)S8
(Gatti and Pimpinelli, 1983)
Df(YL)S13
(Gatti and Pimpinelli, 1983)
Df(YS)A6
(Hazelrigg et al., 1982)
Df(YS)B13
(Hazelrigg et al., 1982)
In(YL)B2
(Gatti and Pimpinelli, 1983)
In(YL)B3
(Gatti and Pimpinelli, 1983)
In(YLS)B1
(Gatti and Pimpinelli, 1983)
T(1;Y)V24
(Gatti and Pimpinelli, 1983)
T(Y;2)A169
(Gatti and Pimpinelli, 1983)
T(Y;2)B3
(Hazelrigg et al., 1982)
T(Y;2)B13
(Hazelrigg et al., 1982)
T(Y;2)B92
(Gatti and Pimpinelli, 1983)
T(Y;2)B242
(Gatti and Pimpinelli, 1983)
T(Y;2)G74
(Gatti and Pimpinelli, 1983)
T(Y;2)J146
(Gatti and Pimpinelli, 1983)
T(Y;2)P57
(Gatti and Pimpinelli, 1983)
T(Y;3)A23
(Gatti and Pimpinelli, 1983)
T(Y;3)A34
(Hazelrigg et al., 1982)
T(Y;3)A112
(Gatti and Pimpinelli, 1983)
T(Y;3)B115
(Gatti and Pimpinelli, 1983)
T(Y;3)B223
(Gatti and Pimpinelli, 1983)
T(Y;3)B229
(Gatti and Pimpinelli, 1983)
T(Y;3)D107
(Gatti and Pimpinelli, 1983)
T(Y;3)S20
(Gatti and Pimpinelli, 1983)
T(Y;3)S21
(Gatti and Pimpinelli, 1983)
Ts(1Lt;YLt)V8
(Zhang and Stankiewicz, 1998)
Ts(1Lt;YLt)W19
(Zhang and Stankiewicz, 1998)
Ts(1Lt;YSt)V24
(Zhang and Stankiewicz, 1998)
Ts(1Lt;YSt)W27
(Zhang and Stankiewicz, 1998)
Ts(YLt;3Rt)A34
(Hazelrigg et al., 1982)
Ts(YLt;4Lt)B15
(Hazelrigg et al., 1982)
Gene partially disrupted in
In(YL)S15
(Gatti and Pimpinelli, 1983)
Inferred from location ( 0 )
    Variants
    Variant Molecular Consequences
    Alleles Representing Disease-Implicated Variants
    Phenotypes
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Human Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Homo sapiens (Human) (16)
    Hsap\DNAH2
    12 of 14
    Yes
    Yes
    Hsap\DNAH9
    4 of 14
    No
    No
    Hsap\DNAH10
    4 of 14
    No
    No
    Hsap\DNAH11
    4 of 14
    No
    No
    Hsap\DNAH14
    4 of 14
    No
    Yes
    Hsap\DNAH17
    4 of 14
    No
    No
    Hsap\DNAH1
    3 of 14
    No
    No
    Hsap\DNAH6
    3 of 14
    No
    No
    Hsap\DNAH3
    2 of 14
    No
    No
    Hsap\DNAH5
    2 of 14
    No
    No
    Hsap\DNAH7
    2 of 14
    No
    No
    Hsap\DNAH8
    2 of 14
    No
    No
    Hsap\DNAH12
    2 of 14
    No
    No
    Hsap\DYNC1H1
    2 of 14
    No
    No
    Hsap\DYNC2H1
    2 of 14
    No
    No
    Hsap\DNHD1
    1 of 14
    No
    No
    Model Organism Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Rattus norvegicus (Norway rat) (15)
    Rnor\Dnah2
    12 of 14
    Yes
    Yes
    Rnor\Dnah9
    4 of 14
    No
    No
    Rnor\Dnah11
    4 of 14
    No
    No
    Rnor\Dnah17
    4 of 14
    No
    No
    Rnor\Dnah1
    3 of 14
    No
    No
    Rnor\Dnah6
    3 of 14
    No
    No
    Rnor\Dnah5
    2 of 14
    No
    No
    Rnor\Dnah7
    2 of 14
    No
    No
    Rnor\Dnah8
    2 of 14
    No
    No
    Rnor\Dnah12
    2 of 14
    No
    No
    Rnor\Dync1h1
    2 of 14
    No
    No
    Rnor\Dync2h1
    2 of 14
    No
    No
    Rnor\Dnah10
    1 of 14
    No
    No
    Rnor\Dnah14
    1 of 14
    No
    Yes
    Rnor\Dnhd1
    1 of 14
    No
    No
    Mus musculus (laboratory mouse) (19)
    Mmus\Dnah2
    12 of 14
    Yes
    Yes
    Mmus\Dnah9
    4 of 14
    No
    No
    Mmus\Dnah10
    4 of 14
    No
    No
    Mmus\Dnah11
    4 of 14
    No
    No
    Mmus\Dnah17
    4 of 14
    No
    No
    Mmus\Dnah1
    3 of 14
    No
    No
    Mmus\Dnah6
    3 of 14
    No
    No
    Mmus\Dnah14
    3 of 14
    No
    Yes
    Mmus\Dnah3
    2 of 14
    No
    No
    Mmus\Dnah5
    2 of 14
    No
    No
    Mmus\Dnah7a
    2 of 14
    No
    No
    Mmus\Dnah7b
    2 of 14
    No
    No
    Mmus\Dnah7c
    2 of 14
    No
    No
    Mmus\Dnah8
    2 of 14
    No
    No
    Mmus\Dnah12
    2 of 14
    No
    No
    Mmus\Dync1h1
    2 of 14
    No
    No
    Mmus\Dync2h1
    2 of 14
    No
    No
    Mmus\Dnhd1
    1 of 14
    No
    No
    Mmus\Map1lc3b
    1 of 14
    No
    No
    Xenopus tropicalis (Western clawed frog) (15)
    Xtro\dnah2
    10 of 13
    Yes
    Yes
    Xtro\dnah9
    3 of 13
    No
    No
    Xtro\dnah10
    3 of 13
    No
    No
    Xtro\dnah14
    3 of 13
    No
    Yes
    Xtro\LOC100497531
    3 of 13
    No
    No
    Xtro\dnah6
    2 of 13
    No
    No
    Xtro\dnah11
    2 of 13
    No
    No
    Xtro\dnah1
    1 of 13
    No
    No
    Xtro\dnah5
    1 of 13
    No
    No
    Xtro\dnah12
    1 of 13
    No
    No
    Xtro\dync1h1
    1 of 13
    No
    No
    Xtro\LOC100488102
    1 of 13
    No
    No
    Xtro\LOC100488188
    1 of 13
    No
    Yes
    Xtro\LOC100490346
    1 of 13
    No
    No
    Xtro\spred1
    1 of 13
    No
    No
    Danio rerio (Zebrafish) (16)
    Drer\dnah2
    12 of 14
    Yes
    Yes
    Drer\dnah9l
    4 of 14
    No
    No
    Drer\dnah10
    4 of 14
    No
    No
    Drer\LOC567790
    4 of 14
    No
    No
    Drer\dnah1
    3 of 14
    No
    No
    Drer\dnah5
    2 of 14
    No
    No
    Drer\dnah5l
    2 of 14
    No
    No
    Drer\dnah6
    2 of 14
    No
    No
    Drer\dnah7
    2 of 14
    No
    No
    Drer\dnah12
    2 of 14
    No
    No
    Drer\dync2h1
    2 of 14
    No
    No
    Drer\dnah3
    1 of 14
    No
    No
    Drer\dnah9
    1 of 14
    No
    No
    Drer\dync1h1
    1 of 14
    No
    No
    Drer\LOC110437768
    1 of 14
    No
    No
    Drer\LOC110439139
    1 of 14
    No
    Yes
    Caenorhabditis elegans (Nematode, roundworm) (2)
    Cele\che-3
    3 of 14
    Yes
    No
    Cele\dhc-1
    3 of 14
    Yes
    No
    Anopheles gambiae (African malaria mosquito) (12)
    Agam\AgaP_AGAP001660
    3 of 12
    Yes
    No
    Agam\AgaP_AGAP001672
    3 of 12
    Yes
    No
    Agam\AgaP_AGAP009550
    3 of 12
    Yes
    No
    Agam\AgaP_AGAP010435
    3 of 12
    Yes
    No
    Agam\AgaP_AGAP003226
    2 of 12
    No
    No
    Agam\AgaP_AGAP002009
    1 of 12
    No
    No
    Agam\AgaP_AGAP002015
    1 of 12
    No
    No
    Agam\AgaP_AGAP003271
    1 of 12
    No
    No
    Agam\AgaP_AGAP007675
    1 of 12
    No
    No
    Agam\AgaP_AGAP009568
    1 of 12
    No
    No
    Agam\AgaP_AGAP010790
    1 of 12
    No
    No
    Agam\AgaP_AGAP011441
    1 of 12
    No
    No
    Arabidopsis thaliana (thale-cress) (0)
    Saccharomyces cerevisiae (Brewer's yeast) (1)
    Scer\DYN1
    3 of 13
    Yes
    No
    Schizosaccharomyces pombe (Fission yeast) (1)
    Spom\dhc1
    3 of 12
    Yes
    No
    Escherichia coli (enterobacterium) (0)
    Other Organism Orthologs (via OrthoDB)
    Data provided directly from OrthoDB:kl-2. Refer to their site for version information.
    Paralogs
    Downloads
    Download All DIOPT Paralogs
    Paralogs (via DIOPT v9.1)
    Gene Symbol
    Score
    Source
    Compara
    Domainoid
    eggNOG
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Drosophila melanogaster (Fruit fly) (14)
    CG3339
    8 of 13
    Dhc93AB
    8 of 13
    Dhc98D
    8 of 13
    Dhc16F
    7 of 13
    kl-5
    7 of 13
    Dhc1
    6 of 13
    Dhc36C
    6 of 13
    Dhc64C
    6 of 13
    kl-3
    6 of 13
    btv
    5 of 13
    CG9068
    5 of 13
    Dnah3
    5 of 13
    Dhc62B
    4 of 13
    sac
    1 of 13
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 1 )
      Human Ortholog
      Disease
      Evidence
      References
      DNAH2; dynein axonemal heavy chain 2
      model of  spermatogenic failure 45
      IEA
      (FlyBase, 2019-)
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      DNAH2; dynein axonemal heavy chain 2
      12 of 14
      603333
      DNAH9; dynein axonemal heavy chain 9
      4 of 14
      603330
      DNAH10; dynein axonemal heavy chain 10
      4 of 14
      605884
      DNAH11; dynein axonemal heavy chain 11
      4 of 14
      603339
      DNAH14; dynein axonemal heavy chain 14
      4 of 14
      603341
          DNAH17; dynein axonemal heavy chain 17
          4 of 14
          610063
          DNAH1; dynein axonemal heavy chain 1
          3 of 14
          603332
          DNAH6; dynein axonemal heavy chain 6
          3 of 14
          603336
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              esyN Network Diagram
              Interactions Browser
              Summary of Genetic Interactions
              esyN Network Diagram
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              External Data
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              External Data
              Linkouts
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              Y
              Recombination map
              Y-
              Cytogenetic map
              h10-h11
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              h10-h11
              Left limit from complementation mapping against T(Y;2)R155 (FBrf0039037) Right limit from complementation mapping against In(YL)S16L (FBrf0039037)
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              h10-h11
              (Drosophila Heterochromatin Genome Project, 2004)
              Experimentally Determined Recombination Data
              Location

              Y-

              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (2)
              Genomic Clones (2)
               

              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

              cDNA Clones (158)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments

                      Sequence of transcript(s) changed in r6 genomic release relative to r5 release.

                      (FlyBase Genome Annotators, 2014)

                      Transiently named CG40438 in release 3 of the genome annotation.

                      (FlyBase Genome Annotators, 2002-2003)

                      Males deficient or mutant for kl-2 are sterile; primary ultrastructural lesion not identified. Such sterile males lack a 300-325 kilodalton sperm polypeptide thought to be a structural component of the axoneme (Goldstein, Hardy and Lindsley, 1982; Hardy, Lindsley, Livak, Lewis, Sivertsen, Joslyn, Edwards and Bonaccorsi, 1984).

                      Relationship to Other Genes
                      Source for database merge of

                      Source for merge of: kl-2 CG17866

                      (FlyBase, 1996-)
                      Additional comments

                      Source for merge of kl-2 CG17866 was sequence comparison ( date:001108 ).

                      (FlyBase, 1996-)

                      Williamson (1972) reported five EMS induced complementing alleles.

                      Nomenclature History
                      Source for database identify of
                      Nomenclature comments
                      Etymology
                      Synonyms and Secondary IDs (9)
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 50 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                      Other crossreferences
                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      FlyMine - An integrated database for Drosophila genomics
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      Linkouts
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Flygut - An atlas of the Drosophila adult midgut
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                      References (94)