Gene Group: PROTEIN TRANSLOCASES, DISLOCASES AND MEMBRANE INSERTASES

General Information

Name

PROTEIN TRANSLOCASES, DISLOCASES AND MEMBRANE INSERTASES

Species

D. melanogaster

Symbol

PTMI

FlyBase ID

FBgg0001932

Date last reviewed

2024-02-29

Number of members

Description

Protein translocases, dislocases and membrane insertases mediate the transport of proteins with respect to a cellular membrane. Protein translocases facilitate the movement of proteins across a membrane. Membrane insertases facilitate the movement of proteins into a membrane bilayer. Protein dislocases remove mislocalized membrane proteins from organelle membranes.

Notes on Group

Source Material

The PROTEIN TRANSLOCASES, DISLOCASES AND MEMBRANE INSERTASES Gene Group has been compiled using the following publication(s): Attrill, 2024.1.5, Attrill, 2023.5.17, Birker et al., 2023, Kaneko, 2022, Periasamy et al., 2022, Metwally et al., 2021, Xiong et al., 2019, Thompson et al., 2018, Vedelek et al., 2018, Yoon et al., 2017, Huynen et al., 2016, Žarsky and Doležal, 2016, Lotz et al., 2014, Faust et al., 2012, Roy et al., 2012, Garabedian et al., 2011, Tan et al., 2009, Langille and Clark, 2007, Sugiyama et al., 2007, Abrams and Andrew, 2005, Hwa et al., 2004, Sardiello et al., 2003.6.11, Becker et al., 2001, and Bomer et al., 1996 .

Key Gene Ontology (GO) terms

Molecular Function

protein transporter activity

protein carrier chaperone

Biological Process

protein transport

Cellular Component

membrane

Related Gene Groups

Parent group(s)

TRANSMEMBRANE TRANSPORTERS

Component group(s)

DISLOCASES

ER MEMBRANE PROTEIN COMPLEXES

GENERAL SECRETORY PATHWAY FAMILY

MITOCHONDRIAL PROTEIN TRANSLOCASE SUBUNITS

PEROXISOMAL TARGETING SYSTEM

PROTEIN-TRANSPORTING ATPASES

YIDC/ALB3/OXA1 MEMBRANE PROTEIN INSERTASE FAMILY

Members (74)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

DISLOCASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG4701

BG:DS06874.3

(FlyBase, 2017-)

CG6230

BcDNA:GH06032

(FlyBase, 2017-)

nmd

no mitochondrial derivative

l(2)08774, Msp1

(FlyBase, 2017-)

ER MEMBRANE PROTEIN COMPLEX EMC2A VARIANT

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

EMC1

ER membrane protein complex subunit 1

(Xiong et al., 2019)

EMC2A

ER membrane protein complex subunit 2A

(Xiong et al., 2019)

EMC3

ER membrane protein complex subunit 3

(Xiong et al., 2019)

EMC4

ER membrane protein complex subunit 4

(Xiong et al., 2019)

EMC5

ER membrane protein complex subunit 5

(Xiong et al., 2019)

EMC6

ER membrane protein complex subunit 6

(Xiong et al., 2019)

EMC7

ER membrane protein complex subunit 7

(Xiong et al., 2019)

EMC8-9

ER membrane protein complex subunit 8/9

(Xiong et al., 2019)

EMC10

ER membrane protein complex subunit 10

(Xiong et al., 2019)

ER MEMBRANE PROTEIN COMPLEX EMC2B VARIANT

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

EMC1

ER membrane protein complex subunit 1

(Xiong et al., 2019)

EMC2B

ER membrane protein complex subunit 2B

(Xiong et al., 2019)

EMC3

ER membrane protein complex subunit 3

(Xiong et al., 2019)

EMC4

ER membrane protein complex subunit 4

(Xiong et al., 2019)

EMC5

ER membrane protein complex subunit 5

(Xiong et al., 2019)

EMC6

ER membrane protein complex subunit 6

(Xiong et al., 2019)

EMC7

ER membrane protein complex subunit 7

(Xiong et al., 2019)

EMC8-9

ER membrane protein complex subunit 8/9

(Xiong et al., 2019)

EMC10

ER membrane protein complex subunit 10

(Xiong et al., 2019)

PEROXISOMAL CARGO RECEPTORS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Pex5

Peroxin 5

EG:63B12.5

(Faust et al., 2012)

Pex7

Peroxin 7

(Faust et al., 2012)

PEROXISOMAL DOCKING AND TRANSLOCATION MODULE

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Pex13

Peroxin 13

(Faust et al., 2012)

Pex14

Peroxin 14

(Faust et al., 2012)

PEROXISOMAL MEMBRANE EXTRACTION COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Pex1

Peroxin 1

l(3)70Da, l(3)s4868, l(3)02402, l(3)S084807, lethal (3) 70Da

(Faust et al., 2012)

Pex6

Peroxin 6

(Faust et al., 2012)

PEROXISOMAL MEMBRANE PROTEIN INSERTION FACTORS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Pex3

Peroxin 3

(Faust et al., 2012)

Pex16

Peroxin 16

(Faust et al., 2012)

Pex19

Peroxin 19

(Faust et al., 2012)

PEROXISOMAL UBIQUITIN LIGASE RETROTRANSLOCON COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Pex2

Peroxin 2

(Faust et al., 2012)

Pex10

Peroxin 10

(Faust et al., 2012)

Pex12

Peroxin 12

(Faust et al., 2012)

PRESEQUENCE TRANSLOCASE-ASSOCIATED MOTOR SUBUNITS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

blp

black pearl

l(3)01618

(Roy et al., 2012, Becker et al., 2001)

CG1409

(Vedelek et al., 2018, Becker et al., 2001)

CG7394

(Becker et al., 2001)

CG11779

(Sardiello et al., 2003.6.11)

Hsc70-5

Heat shock protein 70 cognate 5

Hsc5, Hsc70, Heat shock protein cognate 5, l(2)k04907, Heat shock 70 kDa protein cognate 5

(Kaneko, 2022, Tan et al., 2009)

Roe1

(Yoon et al., 2017, Tan et al., 2009)

PROTEIN-TRANSPORTING ATPASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Bcs1

Bcs1 chaperone

(FlyBase, 2017-)

Hsc70-3

Heat shock protein 70 cognate 3

BiP, Hsc3, Hsc70, Grp78, Hsc-70-3

(FlyBase, 2017-)

Hsc70-5

Heat shock protein 70 cognate 5

Hsc5, Hsc70, Heat shock protein cognate 5, l(2)k04907, Heat shock 70 kDa protein cognate 5

(FlyBase, 2017-)

SEC61 TRANSLOCON - CG8860 VARIANT

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG8860

(Attrill, 2023.5.17, Abrams and Andrew, 2005)

Sec61α

Sec61 α subunit

endd2, Sec61, E(br)165, l(2)k04917, DSec61α

(Abrams and Andrew, 2005)

Sec61β

Sec61 β subunit

l(2)07214, Sec61, DSec61β

(Abrams and Andrew, 2005)

SEC61 TRANSLOCON - SEC61γ VARIANT

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Sec61α

Sec61 α subunit

endd2, Sec61, E(br)165, l(2)k04917, DSec61α

(Abrams and Andrew, 2005)

Sec61β

Sec61 β subunit

l(2)07214, Sec61, DSec61β

(Abrams and Andrew, 2005)

Sec61γ

Sec61 γ subunit

Sec61

(Attrill, 2023.5.17, Abrams and Andrew, 2005)

SEC61 TRANSLOCON - TESTIS-SPECIFIC VARIANT

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG13426

(Attrill, 2023.5.17)

Sec61α

Sec61 α subunit

endd2, Sec61, E(br)165, l(2)k04917, DSec61α

(Abrams and Andrew, 2005)

Sec61β

Sec61 β subunit

l(2)07214, Sec61, DSec61β

(Abrams and Andrew, 2005)

SEC62/SEC63 COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Sec63

Secretory 63

(Abrams and Andrew, 2005)

Trp1

Translocation protein 1

Dtrp1

(Abrams and Andrew, 2005)

SORTING AND ASSEMBLY MACHINERY COMPLEX SUBUNITS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5662

(Huynen et al., 2016, Sardiello et al., 2003.6.11)

CG7639

(Birker et al., 2023, Huynen et al., 2016)

CG8004

(Huynen et al., 2016, Sardiello et al., 2003.6.11)

CG9393

(Huynen et al., 2016, Sardiello et al., 2003.6.11)

TIM17 FAMILY

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG1724

(Žarsky and Doležal, 2016, Sardiello et al., 2003.6.11)

Tim17a1

(Žarsky and Doležal, 2016, Langille and Clark, 2007, Sardiello et al., 2003.6.11)

Tim17a2

(Žarsky and Doležal, 2016, Langille and Clark, 2007, Sardiello et al., 2003.6.11)

Tim17b

Translocase of the inner mitochondrial membrane 17b

(Žarsky and Doležal, 2016, Garabedian et al., 2011)

Tim17b1

(Žarsky and Doležal, 2016, Garabedian et al., 2011, Sardiello et al., 2003.6.11)

Tim17b2

Translocase inner membrane 17

BG:DS01845.2

(Žarsky and Doležal, 2016, Sardiello et al., 2003.6.11, Bomer et al., 1996)

TIM22 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG14270

(Attrill, 2024.1.5)

CG31229

(Attrill, 2024.1.5)

Mulk

Multi-substrate lipid kinase

anon-31BCb

(Attrill, 2024.1.5)

Tim9a

(Attrill, 2024.1.5)

Tim9b

Translocase of inner membrane 9b

Tim9

(Attrill, 2024.1.5)

Tim10

Translocase of inner membrane 10

(Attrill, 2024.1.5)

TIM23^SORT-SPECIFIC SUBUNITS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG6878

Romo1

(Žarsky and Doležal, 2016)

CG7382

(Lotz et al., 2014)

TIM23 FAMILY

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Tim23

Translocase of inner mitochondrial membrane 23

(Periasamy et al., 2022, Žarsky and Doležal, 2016)

TIM50 PRESEQUENCE RECEPTOR SUBUNITS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

ttm2

tiny tim 2

(Sugiyama et al., 2007)

ttm3

tiny tim 3

(Sugiyama et al., 2007)

ttm50

tiny tim 50

EG:95B7.3, Gp99

(Metwally et al., 2021, Sugiyama et al., 2007)

TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE COMPLEX

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

mge

maggie

l(3)63Fc, Tom22

(Periasamy et al., 2022)

Tom5

Translocase of outer membrane 5

(Periasamy et al., 2022)

Tom6

Translocase of outer membrane 6

Dm_2R:4171

(Periasamy et al., 2022)

Tom7

Translocase of outer membrane 7

(Periasamy et al., 2022)

Tom20

Translocase of outer membrane 20

(Periasamy et al., 2022)

Tom40

Translocase of outer membrane 40

dtom40, l(1)G0216

(Periasamy et al., 2022)

Tom70

Translocase of outer membrane 70

(Periasamy et al., 2022)

TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE COMPLEX - TESTIS-SPECIFIC VARIANT

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

mge

maggie

l(3)63Fc, Tom22

(Periasamy et al., 2022, Hwa et al., 2004)

Tom5

Translocase of outer membrane 5

(Periasamy et al., 2022)

Tom6

Translocase of outer membrane 6

Dm_2R:4171

(Periasamy et al., 2022)

Tom7

Translocase of outer membrane 7

(Periasamy et al., 2022, Hwa et al., 2004)

Tom70

Translocase of outer membrane 70

(Periasamy et al., 2022, Hwa et al., 2004)

tomboy20

(Hwa et al., 2004)

tomboy40

(Hwa et al., 2004)

TRANSLOCON-ASSOCIATED PROTEINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Tapδ

Translocon-associated protein δ

Translocon-associated protein delta, l(2)k17005

(Abrams and Andrew, 2005)

TRAM

EG:BACR7A4.5

(Abrams and Andrew, 2005)

YIDC/ALB3/OXA1 MEMBRANE PROTEIN INSERTASE FAMILY

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

OXA1L

OXA1L mitochondrial inner membrane protein

OXA1, BcDNA:GH02220

(Thompson et al., 2018)

External Data

Equivalent Group(s)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

PTMI

PROTEIN TRANSOLCASES AND MEMBRANE INSERTASES

PROTEIN TRANSLOCASES, DISLOCASES AND MEMBRANE INSERTASES

PROTEIN TRANSLOCASES AND MEMBRANE INSERTASES

Secondary FlyBase ID(s)

References (26)

Report Sections

Open Close