FB2024_02 , released April 23, 2024
Gene Group - Macromolecular Complex: RNASE MRP COMPLEX
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General Information
Name
RNASE MRP COMPLEX
Species
D. melanogaster
Symbol
RNASEMRP
FlyBase ID
FBgg0001676
Date last reviewed
2023-08-08
Number of members
9
Description
Description
RNase MRP processes ribosomal RNA (rRNA) precursors at the A3 site allowing formation of the 5.8S pre-rRNA. It is a ribonucleoprotein (RNP) complex, structurally and evolutionary related to the nuclear RNase P, and is found only in eukaryotes. RNase MRP shares most of its protein subunits with nuclear RNase P, though has a distinct catalytic RNA subunit. (Adapted from PMID:16998185 and PMID:20627997.)
Notes on Group

Most protein subunits of yeast and human RNase P are shared with RNase MRP. THe exception is Rpr2/Rpp21, which is known to be unique to RNase P, while there is some evidence that other human RNase P subunits are absent from RNase MRP (see PMID: 20627997). The composition of D. melanogaster RNase MRP has not been assessed,and so all RNase P protein subunits excepting Rpp21 have been included here.

Source Material
The RNASE MRP COMPLEX Gene Group has been compiled using the following publication(s): Manivannan et al., 2015, Schneider et al., 2010, Rosenblad et al., 2006, and Piccinelli et al., 2005 .
Key Gene Ontology (GO) terms
Molecular Function
ribonuclease MRP activity
Biological Process
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Cellular Component
ribonuclease MRP complex
Related Gene Groups
Protein Complex group(s)
NUCLEAR RNASE P COMPLEX
Members (9)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Pop1
POP1 ribonuclease P/MRP subunit
l(1)G0045, BcDNA:LD21623, l(1)G0312
(Rosenblad et al., 2006)
Pop4
POP4 ribonuclease P/MRP subunit
(Rosenblad et al., 2006)
Pop5
POP5 ribonuclease P/MRP subunit
(Rosenblad et al., 2006)
RNaseMRP:RNA
Ribonuclease MRP RNA
MRP RNA, snmRNA:342, RNase MRP
(Manivannan et al., 2015, Schneider et al., 2010, Piccinelli et al., 2005)
Rpp14a
Ribonuclease P/MRP subunit p14 a
Rpp14
(Rosenblad et al., 2006)
Rpp14b
Ribonuclease P/MRP subunit p14 b
Rpp14
(Rosenblad et al., 2006)
Rpp20
Ribonuclease P protein subunit p20
Pop7
(Rosenblad et al., 2006)
Rpp25
Ribonuclease P/MRP subunit p25
(Rosenblad et al., 2006)
Rpp30
RNaseP protein p30
l(2)k01901, coconut, Rpp1
(Rosenblad et al., 2006)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RNASEMRP
RNASE MRP COMPLEX
Secondary FlyBase ID(s)
References (5)