FB2024_02 , released April 23, 2024
Gene Group: ASTACINS
Open Close
General Information
Name
ASTACINS
Species
D. melanogaster
Symbol
AST
FlyBase ID
FBgg0001447
Date last reviewed
2020-06-08
Number of members
13
Description
Description
Astacins belong to MEROPS family M12, subfamily A, and also to the group of peptidases known as the "metzincins", due to a conserved methionine C-terminal to the zinc ligands. They are multi-domain metallopeptidases with manifold functions in metabolism. They are either secreted or membrane-anchored. (Adapted from FBrf0239469 and PMID:23092796.)
Notes on Group
Source Material
The ASTACINS Gene Group has been compiled using the following publication(s): Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Molecular Function
metalloendopeptidase activity
Biological Process
proteolysis
Cellular Component
extracellular space
Enzymatic activity
Enzyme name (EC)
3.4.24.-
Related Gene Groups
Parent group(s)
METZINCINS
PEPTIDASE FAMILY M12
Members (13)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG5715
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG6696
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG6763
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG6974
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG7631
BG:BACR44L22.6
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG10280
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG11865
BG:BACR44L22.4
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG15253
BG:BACR44L22.3
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG15254
BG:BACR44L22.2
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
CG15255
BG:BACR44L22.1
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
Semp1
Seminal metalloprotease-1
BG:BACR44L22.8
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
tld
tolloid
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
tok
tolkin
tlr, tolloid-related 1, tlr-1, tldr-1, tolloid-related
(FlyBase, 2017-, Rawlings and Barrett, 1996-)
External Data
Equivalent Group(s)
Other resource(s)

[MEROPS Family M12](https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=m12)

Synonyms and Secondary IDs
Synonym(s)
AST
ASTACINS
Secondary FlyBase ID(s)
References (3)