FB2024_02 , released April 23, 2024
Gene Group: M13 METALLOENDOPEPTIDASES
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General Information
Name
M13 METALLOENDOPEPTIDASES
Species
D. melanogaster
Symbol
M13
FlyBase ID
FBgg0000963
Date last reviewed
2018-07-19
Number of members
28
Description
Description
The M13 family of endopeptidases are zinc-metalloenzymes, the majority of which are type II integral membrane proteins. The best characterised of this family is vertebrate neprilysin, which has important roles in inactivating signalling peptides involved in modulating neuronal activity, blood pressure, the immune system and reproduction. Other family members are also known or predicted to have biological roles regulating peptide signalling. Insect genomes have an expanded set of M13 metalloendopeptidases. Some of these possess all four characterized motifs required for catalytic activity of vertebrate neprilysin (and are classed as NEPRILYSINS in FlyBase), though most lack one or more of these motifs are likely inactive peptidases (classed here as NEPRILYSIN-LIKE). (Adapted from FBrf0204608.)
Notes on Group
Source Material
The M13 METALLOENDOPEPTIDASES Gene Group has been compiled using the following publication(s): Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, and Rawlings and Barrett, 1996- .
Key Gene Ontology (GO) terms
Molecular Function
metalloendopeptidase activity
Biological Process
proteolysis
Cellular Component
membrane
Enzymatic activity
Enzyme name (EC)
3.4.24.-
Related Gene Groups
Component group(s)
NEPRILYSIN-LIKE METALLOENDOPEPTIDASES
NEPRILYSINS
Members (28)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
NEPRILYSIN-LIKE METALLOENDOPEPTIDASES
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
frma
fra mauro
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)
goe
gone early
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)
Nepl3
Neprilysin-like 3
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)
Nepl4
Neprilysin-like 4
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)
Nepl5
Neprilysin-like 5
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)
Nepl6
Neprilysin-like 6
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)
Nepl7
Neprilysin-like 7
(Meyer et al., 2021, Meyer et al., 2018.7.18, Bland et al., 2008, Rawlings and Barrett, 1996-)
Nepl8
Neprilysin-like 8
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)
Nepl9
Neprilysin-like 9
(Meyer et al., 2021, Meyer et al., 2018.7.18, Rawlings and Barrett, 1996-)
Nepl10
Neprilysin-like 10
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)
Nepl11
Neprilysin-like 11
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)
Nepl12
Neprilysin-like 12
(Meyer et al., 2021, Meyer et al., 2018.7.18, Bland et al., 2008, Rawlings and Barrett, 1996-)
Nepl13
Neprilysin-like 13
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)
Nepl14
Neprilysin-like 14
(Meyer et al., 2021, Meyer et al., 2018.7.18, Rawlings and Barrett, 1996-)
Nepl15
Neprilysin-like 15
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)
Nepl16
Neprilysin-like 16
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)
Nepl17
Neprilysin-like 17
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)
Nepl18
Neprilysin-like 18
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)
Nepl19
Neprilysin-like 19
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)
Nepl20
Neprilysin-like 20
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)
Nepl21
Neprilysin-like 21
(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)
NEPRILYSINS
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Nep1
Neprilysin 1
dNEP1
(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, Rawlings and Barrett, 1996-)
Nep2
Neprilysin 2
dNEP2
(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, Rawlings and Barrett, 1996-)
Nep3
Neprilysin 3
dNEP3
(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, Rawlings and Barrett, 1996-)
Nep4
Neprilysin 4
(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, Rawlings and Barrett, 1996-)
Nep5
Neprilysin 5
(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Meyer et al., 2011, Bland et al., 2008, Rawlings and Barrett, 1996-)
Nep6
Neprilysin 6
(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Rawlings and Barrett, 1996-)
Nep7
Neprilysin 7
(Meyer et al., 2021, Meyer et al., 2018.7.18, FlyBase, 2017-, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
M13
M13 METALLOENDOPEPTIDASES
Secondary FlyBase ID(s)
References (8)