FB2024_02 , released April 23, 2024
Gene Group: BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS
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General Information
Name
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS
Species
D. melanogaster
Symbol
BHLH
FlyBase ID
FBgg0000727
Date last reviewed
2017-06-07
Number of members
59
Description
Description
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Notes on Group
Source Material
The BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS Gene Group has been compiled using the following publication(s): Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, and Ledent and Vervoort, 2001 .
Key Gene Ontology (GO) terms
Molecular Function
DNA-binding transcription factor activity
transcription cis-regulatory region binding
Biological Process
regulation of DNA-templated transcription
Cellular Component
nucleus
Related Gene Groups
Parent group(s)
BASIC DOMAIN TRANSCRIPTION FACTORS
Members (59)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
ac
achaete
Hw, T5, achaete-scute, EG:125H10.3, AS-C T5
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
amos
absent MD neurons and olfactory sensilla
Tft, Roi
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
ase
asense
EG:165H7.2, T1a, T8, AS-C T8
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
ato
atonal
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
bigmax
bigmax
Mlx
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
cato
cousin of atonal
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
CG33557
(Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
Clk
Clock
dClk, dClock, Jrk
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
crp
cropped
l(2)35Fd, dAP-4, AP-4, BG:DS02740.3
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
cwo
clockwork orange
(Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
cyc
cycle
dbmal1, BMAL1, dCYC
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
da
daughterless
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
dimm
dimmed
Mistr, c929
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
dpn
deadpan
44C
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
dysf
dysfusion
dys, cranky, dNXFL
(Shaman et al., 2014, Ledent and Vervoort, 2001)
E(spl)m3-HLH
Enhancer of split m3, helix-loop-helix
m3, E(spl)m3, HLHm3, E(spl)-m3, E(spl)C m3
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
E(spl)m5-HLH
Enhancer of split m5, helix-loop-helix
m5, E(spl)m5, HLHm5, HLH-m5, E(spl) region transcript m5
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
E(spl)m7-HLH
Enhancer of split m7, helix-loop-helix
m7, E(spl)m7, HLHm7, E(spl) region transcript m7, E(spl)-m7
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
E(spl)m8-HLH
Enhancer of split m8, helix-loop-helix
E(spl)m8, m8, E(spl), Enhancer of split, E(spl)-m8
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
E(spl)mβ-HLH
Enhancer of split mβ, helix-loop-helix
E(spl)mβ, mβ, HLHmβ, HLHmbeta, E(spl)-mβ
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
E(spl)mδ-HLH
Enhancer of split mδ, helix-loop-helix
mδ, E(spl)mδ, HLHmdelta, HLHmδ, E(spl) region transcript mδ
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
E(spl)mγ-HLH
Enhancer of split mγ, helix-loop-helix
mγ, E(spl)mγ, HLHmγ, HLHmgamma, E(spl) region transcript mγ
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
emc
extra macrochaetae
l(3)05592, ms(3)61CD, Ach, gov, extramacrochaete
(Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
Fer1
48 related 1
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
Fer2
48 related 2
(Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
Fer3
48 related 3
nephew of atonal 3
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
gce
germ cell-expressed bHLH-PAS
Germ cell-expressed, germ-cell expressed
(Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
Hand
Hand
dHand, hand-C
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
Hesr
HES-related
Her
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
Hey
Hairy/E(spl)-related with YRPW motif
Hesr-1
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
HLH3B
Helix loop helix protein 3B
EG:155E2.2
(Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
HLH4C
Helix loop helix protein 4C
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
HLH54F
HLH54F
bHLH54F
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
hry
hairy
h, l(3)08247
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
kn
knot
col, collier, collier/knot, knotted
(Simionato et al., 2007, Ledent and Vervoort, 2001)
l(1)sc
lethal of scute
l'sc, T3, AS-C T3, lsc, EG:198A6.2
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
Max
Max
dMax
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
Met
Methoprene-tolerant
Rst(1)JH, DmMet, Resistance to Juvenile Hormone
(Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
Mitf
Mitf
TFEB, dMitf
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007)
Mnt
Mnt
dMnt, dMad, Mad, Mad-3E, EG:114E2.2
(Pfreundt et al., 2010, Simionato et al., 2007)
Mondo
Mondo
Mio, ChREBP, Mlx interactor
(Shaman et al., 2014, Simionato et al., 2007, Ledent and Vervoort, 2001)
Myc
Myc
dMyc, dm, diminutive, d-myc, c-Myc
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
nau
nautilus
MyoD, Dmyd
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
net
net
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
Oli
Olig family
Doli
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
sage
salivary gland-expressed bHLH
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
sc
scute
sis-b, sisB, T4, Hw, EG:198A6.1
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
Sidpn
similar to Deadpan
Side
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
sim
single-minded
S8, l(3)S8, shm
(Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
sima
similar
HIF-1α, HIF-1a, HIF-1, l(3)j11B7, HIF1α
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
SREBP
Sterol regulatory element binding protein
HLH106, dSREBP, l(3)76BDw, SREBF1, Helix loop helix protein 106
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
ss
spineless
aristapedia, AHR
(Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
tai
taiman
l(2)01351, l(2)k05809, DAIB1, l(2)k05802
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007)
tap
target of Poxn
biparous, bps
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
tgo
tango
dARNT, ARNT, jaywalker, Hif1, HIF-1
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
trh
trachealess
l(3)10512
(Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
twi
twist
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
tx
taxi
dei, delilah, jumper, del
(Shaman et al., 2014, Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
Usf
Usf
dUSF
(Pfreundt et al., 2010, Simionato et al., 2007, Ledent and Vervoort, 2001)
External Data
Synonyms and Secondary IDs
Synonym(s)
BHLH
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS
Basic helix loop helix proteins
Secondary FlyBase ID(s)
References (5)