FB2024_03 , released June 25, 2024
Gene Group: SIRTUIN LYSINE DEACETYLASES
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General Information
Name
SIRTUIN LYSINE DEACETYLASES
Species
D. melanogaster
Symbol
SIRT
FlyBase ID
FBgg0000278
Date last reviewed
2015-06-09
Number of members
5
Description
Description
Sirtuin family members are NAD+-dependent lysine deacetylases that share a common catalytic core domain. (Adapted from FBrf0159755).
Notes on Group

Some Sirtuins possess mono-ADP-ribosyltransferase activity or deacylase activities other than lysine deacetylation (PMID:25955411).

Source Material
The SIRTUIN LYSINE DEACETYLASES Gene Group has been compiled using the following publication(s): Feller et al., 2015, Pandey et al., 2002, and Frye, 2000 .
Key Gene Ontology (GO) terms
Molecular Function
NAD-dependent histone deacetylase activity
Biological Process
post-translational protein modification
Cellular Component
nucleus
Related Gene Groups
Parent group(s)
LYSINE DEACETYLASES
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
Sirt1
Sirtuin 1
Sir2, dSir2
(Feller et al., 2015, Pandey et al., 2002, Frye, 2000)
Sirt2
Sirtuin 2
Sir2, sirtuin, dsirt2
(Feller et al., 2015, Frye, 2000)
Sirt4
Sirtuin 4
(Feller et al., 2015, Pandey et al., 2002, Frye, 2000)
Sirt6
Sirtuin 6
(Feller et al., 2015, Pandey et al., 2002, Frye, 2000)
Sirt7
Sirtuin 7
(Feller et al., 2015, Pandey et al., 2002, Frye, 2000)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
SIRT
SIRTUIN LYSINE DEACETYLASES
NAD+-dependent sirtuin family
Silent information regulator 2 histone deacetylases
Sirtuins
Sir2-like proteins
Sirtuin histone deacetylases
Sir2
Secondary FlyBase ID(s)
References (4)