FB2024_03 , released June 25, 2024
FB2024_03 , released June 25, 2024
CV Term Report
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General Information
Term NAD-dependent histone deacetylase activity ID (Ontology) GO:0017136 (Gene Ontology)
Definition Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone.[ PubMed:28450737 ]
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       5
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 NAD-dependent histone deacetylase activity (all annotations which use CV term, excluding "NOT" statements)       1      5
     enables | NAD-dependent histone deacetylase activity       --       5
Spanning Tree (Parents/Children)
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hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
 |__histone deacetylase activity_______________________
protein lysine deacetylase activity                    |
 |__histone deacetylase activity_______________________|
 |__NAD-dependent protein lysine deacetylase activity__|
histone modifying activity                             |
 |__histone deacetylase activity_______________________|
                                                       NAD-dependent histone deacetylase activity  6 rec.
                                                        |__NAD-dependent histone H3K9 deacetylase activity 1 rec.
                                                        |__NAD-dependent histone H3K14 deacetylase activity
                                                        |__NAD-dependent histone H3K18 deacetylase activity 1 rec.
                                                        |__NAD-dependent histone H3K56 deacetylase activity
                                                        |__NAD-dependent histone H4K16 deacetylase activity
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Is a histone deacetylase activity
NAD-dependent protein lysine deacetylase activity
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Synonyms
  • "SIR2" RELATED
Secondary IDs
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