Scer\GAL4Mef2.PU-mediated expression results in a progressive, age-dependent loss of flight resulting in a penetrant flightless phenotype at 30 days post eclosion. Indirect flight muscle myofibril structure shows marked defects in integrity and sarcomere organization.
The wing notching seen in N55e11/+ females is partially suppressed by expression of P{UAS-mCh.mir-2b.sponge.T} under the control of Scer\GAL4ptc-559.1.